ArticleChild psychiatry and human development2022
A Two-to-Five Year Follow-Up of a Pediatric Acute-Onset Neuropsychiatric Syndrome Cohort.
Article in Child psychiatry and human development, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 38 citations in OpenAlex.
- Developmental Impacts of PANS/PANDAS and Inadequate Support for Children and Families.Child psychiatry and human development · 2026Article
- Recommended Medical Investigations in Pediatric Acute-Onset Neuropsychiatric Syndrome.JAMA network open · 2026Article
- Ultrarare Variants in DNA Damage Repair and Mitochondrial Genes in Pediatric Acute-Onset Neuropsychiatric Syndrome and Acute Behavioral Regression in Neurodevelopmental Disorders.Developmental neuroscience · 2026Article
- Value-Based Management of Pediatric Acute-Onset OCD: A Case Consistent With Possible Pediatric Acute-Onset Neuropsychiatric Syndrome.The Permanente journal · 2026Article
- Sex-associated and disease state-dependent monocyte polarization and CNS-trafficking phenotypes in pediatric acute-onset neuropsychiatric syndrome (PANS).Journal of neuroinflammation · 2025Article
- The Immune/Inflammatory Underpinnings of Neurodevelopmental Disorders and Pediatric Acute-Onset Neuropsychiatric Syndrome: A Scoping Review.International journal of molecular sciences · 2025Article
- Validation of Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS)-Related Pediatric Treatment Evaluation Checklist (PTEC).Pediatric reports · 2025Article
- Occupational performance patterns in children with paediatric acute-onset neuropsychiatric syndrome.Australian occupational therapy journal · 2025Article
- Relationships between sensory reactivity and occupational performance in children with paediatric acute-onset neuropsychiatric syndrome (PANS).Australian occupational therapy journal · 2025Article
- Article
- Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS) and Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS): Immunological Features Underpinning Controversial Entities.Children (Basel, Switzerland) · 2024Review
- Baseline characteristics of children in the International PANS Registry (IPR) Epidemiology Study.BMJ open · 2024Article
- Pediatric acute-onset neuropsychiatric syndrome and pediatric autoimmune neuropsychiatric disorder associated with streptococcal infections: a delphi study and consensus document about definition, diagnostic criteria, treatment and follow-up.Frontiers in immunology · 2024Article
- Immunological characterization of an Italian PANDAS cohort.Frontiers in pediatrics · 2023Article
- Pediatric Acute-Onset Neuropsychiatric Syndrome: Current Perspectives.Neuropsychiatric disease and treatment · 2023Review
- Understanding parental stress among parents of children with Paediatric Acute-onset Neuropsychiatric Syndrome (PANS) in Sweden.International journal of qualitative studies on health and well-being · 2022Article
- Identification of ultra-rare genetic variants in pediatric acute onset neuropsychiatric syndrome (PANS) by exome and whole genome sequencing.Scientific reports · 2022Article
- Youth with severe mental illness and complex non-somatic motor abnormalities: conflicting conceptualizations and unequal treatment.Npj mental health research · 2022Article
- Tourette syndrome research highlights from 2021.F1000Research · 2022Review
- Children With PANS May Manifest POTS.Frontiers in neurology · 2022Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Little is known about the long-term prognosis of children with pediatric acute-onset neuropsychiatric syndrome (PANS). Out of the 46 eligible patients from the Karolinska PANS cohort, 34 consented to participate in a follow-up (median 3.3 years). Participants underwent a thorough clinical evaluation and were classified according to their clinical course. Resulting groups were compared on clinical characteristics and laboratory test results. We observed significant reductions in clinician-rated PANS symptom severity and improved general function. Two patients were classified as remitted, 20 as relapsing-remitting, and 12 as having a chronic-static/progressive course. The latter group had an earlier onset, greater impairment and received more pharmacological and psychological treatments. Although remission was rare, the majority of children with PANS were significantly improved over the follow-up period but a non-negligible minority of patients displayed a chronic-static/progressive course and required additional treatments. The proposed definitions of flare and clinical course may be useful in future clinical trials.
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Registered trials
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