ArticleInternational journal of legal medicine2021
Gene variants associated with obstructive sleep apnea (OSA) in relation to sudden infant death syndrome (SIDS).
Article in International journal of legal medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 10 citations in OpenAlex.
- Influence of Ancestry and Molecular Markers on the Severity of Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis.Sleep science (Sao Paulo, Brazil) · 2026Review
- Early-onset pharyngeal airway collapse in infants: a retrospective single-center study.BMC pediatrics · 2023Article
- A rare early-onset neonatal case of Birk-Barel syndrome presenting severe obstructive sleep apnea: a case report.Frontiers in medicine · 2023Article
- Sudden infant death syndrome revisited: serotonin transporter gene, polymorphisms and promoter methylation.Pediatric research · 2022Article
- Variants in genes encoding the SUR1-TRPM4 non-selective cation channel and sudden infant death syndrome (SIDS): potentially increased risk for cerebral edema.International journal of legal medicine · 2022Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBoth obstructive sleep apnea (OSA) and (at least a fraction of) sudden infant death syndrome (SIDS) are associated with impaired respiration. For OSA, an association with several gene variants was identified. Therefore, our hypothesis is that these polymorphisms might be of relevance in SIDS as well.
methodsTwenty-four single nucleotide polymorphisms (SNPs) in 21 candidate genes connected to OSA, were genotyped in a total of 282 SIDS cases and 374 controls. Additionally, subgroups based on factors codetermining the SIDS risk (age, sex, season, and prone position) were established and compared as well.
resultsTwo of the analyzed SNPs showed nominally significant differences between SIDS and control groups: rs1042714 in ADRB2 (adrenoceptor beta 2) and rs1800541 in EDN1 (endothelin 1). In the subgroup analyses, 10 further SNPs gave significant results. Nevertheless, these associations did not survive adjustment for multiple testing.
conclusionsOur results suggest that there might be a link between SIDS and OSA and its resulting respiratory and cardiovascular problems, albeit this predisposition might be dependent on the combination with other, hitherto unknown gene variants. These findings may encourage replication studies to get a better understanding of this connection.
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