Evidence map›Paper›PMID 33558881›Full record

ReviewEndocrinology2021

Monitoring In Vivo Neural Activity to Understand Gut-Brain Signaling.

Amber L Alhadeff

Abstract readReview
In one paragraph

Review in Endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Trial
  2. GLP-1 physiology and pharmacology along the gut-brain axis.The Journal of clinical investigation · 2026
    Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Glucose Sensing in the Hepatic Portal Vein and Its Role in Food Intake and Reward.Cellular and molecular gastroenterology and hepatology · 2023
    Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Amber L AlhadeffMonell Chemical Senses Center, Philadelphia, PA, USA.

Funding

INVESTIGATING THE GUT-BRAIN SIGNALING DYNAMICS REGULATING FOOD INTAKER00DK119574 · NIDDK · MONELL CHEMICAL SENSES CENTER · PI ALHADEFF, AMBER L · 2020 to 2022
$868k
NIDDK NIH HHS R00 DK119574
6 · The paper itself

Abstract

Appropriate food intake requires exquisite coordination between the gut and the brain. Indeed, it has long been known that gastrointestinal signals communicate with the brain to promote or inhibit feeding behavior. Recent advances in the ability to monitor and manipulate neural activity in awake, behaving rodents has facilitated important discoveries about how gut signaling influences neural activity and feeding behavior. This review emphasizes recent studies that have advanced our knowledge of gut-brain signaling and food intake control, with a focus on how gut signaling influences in vivo neural activity in animal models. Moving forward, dissecting the complex pathways and circuits that transmit nutritive signals from the gut to the brain will reveal fundamental principles of energy balance, ultimately enabling new treatment strategies for diseases rooted in body weight control.

Indexed as

EatingAnimalsBrainFeeding BehaviorGastrointestinal TractHumansSignal Transductioncalcium imagingdopaminegut–brainhindbrainhypothalamusvagus nerve

Identifiers

PMID33558881
PMCPMC7951047

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.