Evidence map›Paper›PMID 33558704›Full record

ReviewCancer gene therapy2021

Nanomedicine-based cancer immunotherapy: recent trends and future perspectives.

Vinoth-Kumar Lakshmanan, Shlok Jindal, Gopinath Packirisamy, Shreesh Ojha, Sen Lian, Ajeet Kaushik, Abdulqadir Ismail M Abdullah Alzarooni, Yasser Abdelraouf Farahat Metwally, Sadras Panchatcharam Thyagarajan, Young Do Jung and 1 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Cancer gene therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
5.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 72 citations in OpenAlex.

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  6. Nanoimmunotherapy: the smart trooper for cancer therapy.Exploration of targeted anti-tumor therapy · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 6 countries.

Vinoth-Kumar Lakshmanan *Centre for Preclinical and Translational Medical Research (CPTMR), Central Research Facility (CRF), Faculty of Clinical Research, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai, Tamil Nadu, India. vinoth.lakshmanan@sriramachandra.edu.in.ORCID http://orcid.org/0000-0002-7420-8459
Shlok Jindal *Department of Biotechnology, Indian Institute of Technology (IIT) Roorkee, Roorkee, Uttarakhand, India.ORCID http://orcid.org/0000-0001-9166-861X
Gopinath PackirisamyDepartment of Biotechnology, Indian Institute of Technology (IIT) Roorkee, Roorkee, Uttarakhand, India. gopi@bt.iitr.ac.in.
Shreesh OjhaDepartment of Pharmacology and Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, Abu Dhabi, United Arab Emirates.
Sen LianDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China.
Ajeet KaushikNanoBio Tech Laboratory, Health System Engineering, Department of Natural Sciences, Division of Sciences, Arts & Mathematics, Florida Polytechnic University, Lakeland, FL, USA.
Abdulqadir Ismail M Abdullah AlzarooniDepartment of Urology, H.H. Sheikh Khalifa General Hospital, Al Salama, Opp. Ministry of Community Development, Umm Al Quwain, United Arab Emirates.
Yasser Abdelraouf Farahat MetwallyDepartment of Urology, H.H. Sheikh Khalifa General Hospital, Al Salama, Opp. Ministry of Community Development, Umm Al Quwain, United Arab Emirates.
Sadras Panchatcharam ThyagarajanCentre for Preclinical and Translational Medical Research (CPTMR), Central Research Facility (CRF), Faculty of Clinical Research, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai, Tamil Nadu, India.
Young Do JungDepartment of Biochemistry, Chonnam National University Medical School, Gwangju, South Korea.
Salem ChouaibThumbay Research Institute for Precision Medicine, Gulf Medical University, Ajman, United Arab Emirates. salem.chouaib@gmu.ac.ae.
Indian Institute of Technology Roorkee · INChonnam National University · KRFlorida Polytechnic University · USGulf Medical University · AESouthern Medical University · CNSri Ramachandra Institute of Higher Education and Research · INUnited Arab Emirates University · AEUniversité Paris-Sud · FR

Funding

Department of Biotechnology, Ministry of Science and Technology (DBT) BT/PR 25095/NER/95/1011/2017
6 · The paper itself

Abstract

The combination of cancer immunotherapy with efficient functionalized nanosystems has emerged as a beneficial treatment strategy and its use has increased rapidly. The roles of stimuli-responsive nanosystems and nanomedicine-based cancer immunotherapy, a subsidiary discipline in the field of immunology, are pivotal. The present era is witnessing rapid advancements in the use of nanomedicine as a platform for investigating novel therapeutic applications and modern intelligent healthcare management strategies. The development of cancer nanomedicine has posthaste ratified the outcomes of immunotherapy to the subsequent stage in the current era of medical research. This review focuses on key findings with respect to the effectiveness of nanomedicine-based cancer immunotherapies and their applications, which include i) immune checkpoint inhibitors and nanomedicine, ii) CRISPR-Cas nanoparticles (NPs) in cancer immunotherapy, iii) combination cancer immunotherapy with core-shell nanoparticles, iv) biomimetic NPs for cancer immunotherapy, and v) CAR-T cells and cancer nanoimmunotherapy. By evaluating the state-of-the-art tools and taking the challenges involved into consideration, various aspects of the proposed nano-enabled therapeutic approaches have been discussed in this review.

Indexed as

HumansImmunotherapyNanomedicineNanoparticlesNeoplasms

Identifiers

PMID33558704
OpenAlexW3127812962

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.