ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2021
Adolescent stress sensitizes the adult neuroimmune transcriptome and leads to sex-specific microglial and behavioral phenotypes.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 36 citations in OpenAlex.
- A neuroimmune framework for understanding adolescent stress and risk of alcohol misuse.Brain, behavior, & immunity - health · 2026Review
- Concurrent consumption of ethanol and corticosterone during adolescence alters neuroimmune sensitivity in Sprague Dawley rats.Addiction neuroscience · 2025Article
- Introduction of novel objects to the home cage of mice repeatedly disturbs sleep for seven days with minimal stress induction.Npj biological timing and sleep · 2025Article
- Social Defeat Stress Model for Adolescent C57BL/6 Male and Female Mice.Journal of visualized experiments : JoVE · 2024Article
- Gains and Losses: Resilience to Social Defeat Stress in Adolescent Female Mice.Biological psychiatry · 2024Article
- Chronic Stress as a Risk Factor for Type 2 Diabetes: Endocrine, Metabolic, and Immune Implications.Endocrine, metabolic & immune disorders drug targets · 2024Review
- Behavior, synaptic mitochondria, and microglia are differentially impacted by chronic adolescent stress and repeated endotoxin exposure in male and female rats.Stress (Amsterdam, Netherlands) · 2024Article
- Epigenetic regulation of microglia and neurons by proinflammatory signaling following adolescent intermittent ethanol (AIE) exposure and in human AUD.Advances in drug and alcohol research · 2024Review
- Post-weaning social isolation alters sociability in a sex-specific manner.Frontiers in behavioral neuroscience · 2024Article
- Chronic adolescent stress alters GR-FKBP5 interactions in the hippocampus of adult female rats.Stress (Amsterdam, Netherlands) · 2024Article
- Repeated social defeat stress leads to immunometabolic shifts in innate immune cells of the spleen.Brain, behavior, & immunity - health · 2023Article
- mGluR5 in hippocampal CA1 pyramidal neurons mediates stress-induced anxiety-like behavior.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- TLR3 activation with poly I:C exacerbates escalated alcohol consumption in dependent male C57BL/6J mice.The American journal of drug and alcohol abuse · 2023Article
- Chronic stress beginning in adolescence decreases spatial memory following an acute inflammatory challenge in adulthood.Behavioural brain research · 2023Article
- Targeting Persistent Changes in Neuroimmune and Epigenetic Signaling in Adolescent Drinking to Treat Alcohol Use Disorder in Adulthood.Pharmacological reviews · 2023Review
- Sex differences in stress-induced alcohol intake: a review of preclinical studies focused on amygdala and inflammatory pathways.Psychopharmacology · 2022Review
- Increased alcohol self-administration following repeated Toll-like receptor 3 agonist treatment in male and female rats.Pharmacology, biochemistry, and behavior · 2022Article
- Adolescent Binge Alcohol Enhances Early Alzheimer's Disease Pathology in Adulthood Through Proinflammatory Neuroimmune Activation.Frontiers in pharmacology · 2022Article
- A molecular framework for autistic experiences: Mitochondrial allostatic load as a mediator between autism and psychopathology.Frontiers in psychiatry · 2022Article
- Uncovering microglial pathways driving sex-specific neurobiological effects in stress and depression.Brain, behavior, & immunity - health · 2021Article
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
Abstract
Adolescent exposure to chronic stress, a risk factor for mood disorders in adulthood, sensitizes the neuroinflammatory response to a subsequent immune challenge. We previously showed that chronic adolescent stress (CAS) in rats led to distinct patterns of neuroimmune priming in adult male and female rats. However, sex differences in the neuroimmune consequences of CAS and their underlying mechanisms are not fully understood. Here we hypothesized that biological sex would dictate differential induction of inflammation-related transcriptomic pathways and immune cell involvement (microglia activation and leukocyte presence) in the hippocampus of male and female rats with a history of CAS. Adolescent rats underwent CAS (six restraint and six social defeat episodes during postnatal days 38-49), and behavioral assessments were conducted in adolescence and adulthood. Neuroimmune measures were obtained following vehicle or a systemic lipopolysaccharide (LPS) challenge in adulthood. CAS led to increased time in the corners of the open field in adolescence. In males, CAS also increased social avoidance. As adults, CAS rats displayed an exaggerated enrichment of the nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) pathway and chemokine induction following LPS challenge, and increased number of perivascular CD45
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.