Evidence map›Paper›PMID 33558650›Full record

SynthesisMolecular psychiatry2022

Gut dysbiosis in severe mental illness and chronic fatigue: a novel trans-diagnostic construct? A systematic review and meta-analysis.

Jenelle Marcelle Safadi, Alice M G Quinton, Belinda R Lennox, Philip W J Burnet, Amedeo Minichino

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Molecular psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
  2. Recent research in myalgic encephalomyelitis/chronic fatigue syndrome: an evidence map.Health technology assessment (Winchester, England) · 2025
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  9. Efficacy ofWorld journal of psychiatry · 2025
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4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jenelle Marcelle SafadiCornell University, Ithaca, NY, USA.
Alice M G QuintonDepartment of Psychiatry, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0001-5563-4893
Belinda R LennoxDepartment of Psychiatry, University of Oxford, Oxford, UK.
Philip W J BurnetDepartment of Psychiatry, University of Oxford, Oxford, UK.
Amedeo MinichinoDepartment of Psychiatry, University of Oxford, Oxford, UK. amedeo.mininichino@psych.ox.ac.uk.ORCID http://orcid.org/0000-0002-6309-6324

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Reduced gut-microbial diversity ("gut dysbiosis") has been associated with an anhedonic/amotivational syndrome ("sickness behavior") that manifests across severe mental disorders and represent the key clinical feature of chronic fatigue. In this systematic review and meta-analysis, we investigated differences in proxy biomarkers of gut dysbiosis in patients with severe mental illness and chronic fatigue vs. controls and the association of these biomarkers with sickness behavior across diagnostic categories. Following PRISMA guidelines, we searched from inception to April 2020 for all the studies investigating proxy biomarkers of gut dysbiosis in patients with severe mental illness and chronic fatigue. Data were independently extracted by multiple observers, and a random-mixed model was used for the analysis. Heterogeneity was assessed with the I

Indexed as

Fatigue Syndrome, ChronicMental DisordersBiomarkersDysbiosisHumansBiomarkers

Identifiers

PMID33558650
PMCPMC8960409

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.