ArticleScientific reports2021
Involvement of MCH-oxytocin neural relay within the hypothalamus in murine nursing behavior.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 15 citations in OpenAlex.
- Distinct projections of PVN oxytocin neurons regulate the divergent defensive behaviors in response to social threat.Science advances · 2026Article
- Sex-associated circadian signaling signatures in the lateral hypothalamus.Frontiers in sleep · 2026Article
- Lack of glutamate neurotransmission in melanin-concentrating hormone neurons alters mouse reproduction and metabolism in a sex-specific manner.Biology of sex differences · 2025Article
- Effect of the neonicotinoid pesticide clothianidin at a no-observed-adverse-effect-level (NOAEL) dose on maternal behavior in pregnant mice and their female offspring.The Journal of veterinary medical science · 2025Article
- The neurobiology of parenting and infant-evoked aggression.Physiological reviews · 2025Review
- Sex differences and sex-specific regulation of motivated behavior by Melanin-concentrating hormone: a short review.Biology of sex differences · 2024Review
- Novel aspect of oxytocin neurons mediating parental behavior and aversive burying behavior under the control of melanin-concentrating hormone neurons.Frontiers in behavioral neuroscience · 2024Article
- Fast neurotransmitter identity of MCH neurons: Do contents depend on context?Frontiers in neuroendocrinology · 2023Review
- Intrahypothalamic effects of oxytocin on PVN CRH neurons in response to acute stress.Current opinion in endocrine and metabolic research · 2022Article
- Partial masculinization of Aedes aegypti females by conditional expression of Nix.PLoS neglected tropical diseases · 2022Article
- Social Network Plasticity of Mice Parental Behavior.Frontiers in neuroscience · 2022Review
- Neural Contributions of the Hypothalamus to Parental Behaviour.International journal of molecular sciences · 2021Review
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multiple sequential actions, performed during parental behaviors, are essential elements of reproduction in mammalian species. We showed that neurons expressing melanin concentrating hormone (MCH) in the lateral hypothalamic area (LHA) are more active in rodents of both sexes when exhibiting parental nursing behavior. Genetic ablation of the LHA-MCH neurons impaired maternal nursing. The post-birth survival rate was lower in pups born to female mice with congenitally ablated MCH neurons under control of tet-off system, exhibiting reduced crouching behavior. Virgin female and male mice with ablated MCH neurons were less interested in pups and maternal care. Chemogenetic and optogenetic stimulation of LHA-MCH neurons induced parental nursing in virgin female and male mice. LHA-MCH GABAergic neurons project fibres to the paraventricular hypothalamic nucleus (PVN) neurons. Optogenetic stimulation of PVN induces nursing crouching behavior along with increasing plasma oxytocin levels. The hypothalamic MCH neural relays play important functional roles in parental nursing behavior in female and male mice.
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