Watching synchronous mitochondrial respiration in the retina and its instability in a mouse model of macular degeneration.

Pardis Kaynezhad, Ilias Tachtsidis, Asmaa Aboelnour, Sobha Sivaprasad, Glen Jeffery

Open access · goldAbstract read

In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it

0cells of the map it votes in

4citing papers in PubMed

0.8field-weighted citation impact, top 30% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

Use ofAging cell · 2023
Article
Watching the human retina breath in real time and the slowing of mitochondrial respiration with age.Scientific reports · 2023
Article
Contribution of animal models to the mechanistic understanding of Alternative Pathway and Amplification Loop (AP/AL)-driven Complement-mediated Diseases.Immunological reviews · 2023
Review
The Role of Neuroglobin in Retinal Hemodynamics and Metabolism: A Real-Time Study.Translational vision science & technology · 2022
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Pardis KaynezhadInstitute of Ophthalmology, University College London, London, EC1V 9EL, UK.

Ilias TachtsidisDepartment of Medical Physics and Biomedical Engineering, University College London, London, WC1E 6BT, UK.

Asmaa AboelnourHistology and Cytology Department, Faculty of Veterinary Medicine, Damanhour University, Damanhour, Egypt.

Sobha SivaprasadInstitute of Ophthalmology, University College London, London, EC1V 9EL, UK.

Glen JefferyInstitute of Ophthalmology, University College London, London, EC1V 9EL, UK. g.jeffery@ucl.ac.uk.

University College London · GBDamanhour University · EG

Funding

Biotechnology and Biological Sciences Research Council BB/N000250/1

6 · The paper itself

Abstract

Mitochondrial function declines with age and in some diseases, but we have been unable to analyze this in vivo. Here, we optically examine retinal mitochondrial function as well as choroidal oxygenation and hemodynamics in aging C57 and complement factor H (CFH

Indexed as

Oxygen ConsumptionAgingAnimalsDisease Models, AnimalMacular DegenerationMiceMice, KnockoutMitochondriaRetina

Identifiers

PMID33558624

DOI10.1038/s41598-021-82811-2

PMCPMC7870852

OpenAlexW3128002001

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.