ArticleScientific reports2021
Evaluating very high energy electron RBE from nanodosimetric pBR322 plasmid DNA damage.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Multiscale Radiobiological Assessment of Laser-Driven Very High Energy Electrons Versus Conventional Electrons.Advances in radiation oncology · 2026Article
- Ultra-high dose rate dependent modeling of plasmid DNA damage with TOPAS-nBio.Physics in medicine and biology · 2026Article
- In vitro oxygen concentration alters reactive oxygen species yields with minor plasmid DNA damage change at ultra-high-dose rate.The British journal of radiology · 2026Article
- Emerging strategies in radiation therapy: promises and challenges of spatial fractionation, ultra-high dose rates, and nanoparticles.Journal of physics D: Applied physics · 2025Review
- Clinical translation of ultra-high dose rate flash radiotherapy: Opportunities, challenges, and prospects.World journal of radiology · 2025Review
- Mechanisms of Action of AGuIX as a Pan-Cancer Nano-Radiosensitizer: A Comprehensive Review.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Plasmid DNA Strand Breaks Are Dose Rate Independent at Clinically Relevant Proton Doses and Under Biological Conditions.Radiation research · 2025Article
- Consensus statement on the exploration of clinical translation and application of electron ultra-high dose rate FLASH radiotherapy.Precision radiation oncology · 2025Article
- Preclinical tumor control with a laser-accelerated high-energy electron radiotherapy prototype.Nature communications · 2025Article
- Probing Spatiotemporal Effects of Intertrack Recombination with a New Implementation of Simultaneous Multiple Tracks in TRAX-CHEM.International journal of molecular sciences · 2025Article
- Review
- The oxygen puzzle in FLASH radiotherapy: A comprehensive review and experimental outlook.Clinical and translational radiation oncology · 2024Review
- VHEE FLASH sparing effect measured at CLEAR, CERN with DNA damage of pBR322 plasmid as a biological endpoint.Scientific reports · 2024Article
- First in vitro measurement of VHEE relative biological effectiveness (RBE) in lung and prostate cancer cells using the ARES linac at DESY.Scientific reports · 2024Article
- Quantification of damage to plasmid DNA from 35 MeV electrons, 228 MeV protons and 300 kVp X-rays in varying hydroxyl radical scavenging environments.Journal of radiation research · 2023Article
- Nanoscopic biodosimetry using plasmid DNA in radiotherapy with metallic nanoparticles.Journal of applied clinical medical physics · 2023Review
- Validation of a High-Throughput Dicentric Chromosome Assay Using Complex Radiation Exposures.Radiation research · 2023Article
- Clustered DNA Damage Patterns after Proton Therapy Beam Irradiation Using Plasmid DNA.International journal of molecular sciences · 2022Article
- A potential revolution in cancer treatment: A topical review of FLASH radiotherapy.Journal of applied clinical medical physics · 2022Review
- New damage model for simulating radiation-induced direct damage to biomolecular systems and experimental validation using pBR322 plasmid.Scientific reports · 2022Article
Corrections and comments
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This paper presents the first plasmid DNA irradiations carried out with Very High Energy Electrons (VHEE) over 100-200 MeV at the CLEAR user facility at CERN to determine the Relative Biological Effectiveness (RBE) of VHEE. DNA damage yields were measured in dry and aqueous environments to determine that ~ 99% of total DNA breaks were caused by indirect effects, consistent with other published measurements for protons and photons. Double-Strand Break (DSB) yield was used as the biological endpoint for RBE calculation, with values found to be consistent with established radiotherapy modalities. Similarities in physical damage between VHEE and conventional modalities gives confidence that biological effects of VHEE will also be similar-key for clinical implementation. Damage yields were used as a baseline for track structure simulations of VHEE plasmid irradiation using GEANT4-DNA. Current models for DSB yield have shown reasonable agreement with experimental values. The growing interest in FLASH radiotherapy motivated a study into DSB yield variation with dose rate following VHEE irradiation. No significant variations were observed between conventional and FLASH dose rate irradiations, indicating that no FLASH effect is seen under these conditions.
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