ArticleNature communications2021
The singularity response reveals entrainment properties of the plant circadian clock.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Parameterized resetting model captures dose-dependent entrainment of the mouse circadian clock.Nature communications · 2025Article
- Diel transcriptional responses of coral-Symbiodiniaceae holobiont to elevated temperature.Communications biology · 2024Article
- Dissecting the complexity of local and systemic circadian communication in plants.Npj biological timing and sleep · 2024Review
- Impact of meteorological variability on diurnal and seasonal net ecosystem productivity in a desert riparian forest ecosystem.Frontiers in plant science · 2024Article
- Investigating Circadian Gating of Temperature Responsive Genes.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Association between circadian syndrome and chronic diarrhea: a cross-sectional study of NHANES 2005-2010 data.Frontiers in physiology · 2024Article
- Singularity response reveals entrainment properties in mammalian circadian clock.Nature communications · 2023Article
- Red Light Resets the Expression Pattern, Phase, and Period of the Circadian Clock in Plants: A Computational Approach.Biology · 2022Article
- Circadian entrainment in Arabidopsis.Plant physiology · 2022Article
- Principles, mechanisms and functions of entrainment in biological oscillators.Interface focus · 2022Review
- Application of time lags between light and temperature cycles for growth control based on the circadian clock ofFrontiers in plant science · 2022Article
- Circa-SCOPE: high-throughput live single-cell imaging method for analysis of circadian clock resetting.Nature communications · 2021Article
- Time Lag Between Light and Heat Diurnal Cycles ModulatesFrontiers in plant science · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Circadian clocks allow organisms to synchronize their physiological processes to diurnal variations. A phase response curve allows researchers to understand clock entrainment by revealing how signals adjust clock genes differently according to the phase in which they are applied. Comprehensively investigating these curves is difficult, however, because of the cost of measuring them experimentally. Here we demonstrate that fundamental properties of the curve are recoverable from the singularity response, which is easily measured by applying a single stimulus to a cellular network in a desynchronized state (i.e. singularity). We show that the singularity response of Arabidopsis to light/dark and temperature stimuli depends on the properties of the phase response curve for these stimuli. The measured singularity responses not only allow the curves to be precisely reconstructed but also reveal organ-specific properties of the plant circadian clock. The method is not only simple and accurate, but also general and applicable to other coupled oscillator systems as long as the oscillators can be desynchronized. This simplified method may allow the entrainment properties of the circadian clock of both plants and other species in nature.
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