Evidence map›Paper›PMID 33558487›Full record

ArticleNature communications2021

Host interneurons mediate plasticity reactivated by embryonic inhibitory cell transplantation in mouse visual cortex.

XiaoTing Zheng, Kirstie J Salinas, Dario X Figueroa Velez, Taylor Nakayama, Xiaoxiao Lin, Dhruba Banerjee, Xiangmin Xu, Sunil P Gandhi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Neural Circuit Mapping and Neurotherapy-Based Strategies.Cellular and molecular neurobiology · 2025
    Review
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  6. Article
  7. Review
  8. Optogenetic Interrogation of Circuits Following Neurotrauma.Frontiers in molecular neuroscience · 2021
    Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

XiaoTing ZhengDepartment of Neurobiology and Behavior, University of California, Irvine, Irvine, CA, 92697-2715, USA.
Kirstie J SalinasDepartment of Neurobiology and Behavior, University of California, Irvine, Irvine, CA, 92697-2715, USA.
Dario X Figueroa VelezDepartment of Neurobiology and Behavior, University of California, Irvine, Irvine, CA, 92697-2715, USA.
Taylor NakayamaDepartment of Neurobiology and Behavior, University of California, Irvine, Irvine, CA, 92697-2715, USA.
Xiaoxiao LinDepartment of Anatomy and Neurobiology, University of California, Irvine, Irvine, CA, 92697-2715, USA.
Dhruba BanerjeeDepartment of Neurobiology and Behavior, University of California, Irvine, Irvine, CA, 92697-2715, USA.
Xiangmin XuDepartment of Anatomy and Neurobiology, University of California, Irvine, Irvine, CA, 92697-2715, USA.
Sunil P GandhiDepartment of Neurobiology and Behavior, University of California, Irvine, Irvine, CA, 92697-2715, USA. sunil.gandhi@uci.edu.
University of California, Irvine · US

Funding

Reorganization of the Central Visual System by Inhibitory Neuron TransplantationR01EY029490 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI LUR, GYORGY · 2019 to 2023
$2.6M
Neuregulin-1 based molecular mechanisms of cortical plasticityR01EY028212 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI GANDHI, SUNIL, XU, XIANGMIN · 2017 to 2020
$1.8M
NEI NIH HHS R01 EY028212NEI NIH HHS R01 EY029490
6 · The paper itself

Abstract

The adult brain lacks sensitivity to changes in the sensory environment found in the juvenile brain. The transplantation of embryonic interneurons has been shown to restore juvenile plasticity to the adult host visual cortex. It is unclear whether transplanted interneurons directly mediate the renewed cortical plasticity or whether these cells act indirectly by modifying the host interneuron circuitry. Here we find that the transplant-induced reorganization of mouse host circuits is specifically mediated by Neuregulin (NRG1)/ErbB4 signaling in host parvalbumin (PV) interneurons. Brief visual deprivation reduces the visual activity of host PV interneurons but has negligible effects on the responses of transplanted PV interneurons. Exogenous NRG1 both prevents the deprivation-induced reduction in the visual responses of host PV interneurons and blocks the transplant-induced reorganization of the host circuit. While deletion of ErbB4 receptors from host PV interneurons blocks cortical plasticity in the transplant recipients, deletion of the receptors from the donor PV interneurons does not. Altogether, our results indicate that transplanted embryonic interneurons reactivate cortical plasticity by rejuvenating the function of host PV interneurons.

Indexed as

Cell TransplantationAnimalsCell DifferentiationDominance, OcularFemaleInterneuronsMaleMiceMice, Inbred C57BLNeuregulin-1Neuronal PlasticityParvalbuminsReceptor, ErbB-4Sensory DeprivationSignal TransductionSynapsesNeuregulin-1ParvalbuminsReceptor, ErbB-4

Identifiers

PMID33558487
PMCPMC7870960
OpenAlexW3128582687

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.