Evidence map›Paper›PMID 33558472›Full record

ArticleCell death & disease2021

Characterization of ferroptosis in kidney tubular cell death under diabetic conditions.

Seonghun Kim, Shin-Wook Kang, Jeongho Joo, Seung Hyeok Han, Huiyoon Shin, Bo Young Nam, Jimin Park, Tae-Hyun Yoo, Gyuri Kim, Pureunchowon Lee and 1 more

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Cell death & disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 196 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
196citing papers in PubMed, 4 pooled it
29.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

196 citing papers in PubMed, 4 syntheses or guidelines pooled it, 289 citations in OpenAlex.

  1. Pooled it
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  10. Ferroptosis as a target mechanism in heart and kidney disease.The Journal of clinical investigation · 2026
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  18. Defective efferocytosis in diabetes: molecular mechanisms and emerging therapeutic strategies.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Review
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136 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Seonghun KimDepartment of Oral Pathology, Oral Cancer Research Institute, College of Dentistry, Yonsei University, Seoul, South Korea.ORCID http://orcid.org/0000-0003-3338-1156
Shin-Wook KangInstitute of Kidney Disease Research, College of Medicine, Yonsei University, Seoul, South Korea.
Jeongho JooDepartment of Internal Medicine, College of Medicine, Yonsei University, Seoul, South Korea.
Seung Hyeok HanInstitute of Kidney Disease Research, College of Medicine, Yonsei University, Seoul, South Korea.ORCID http://orcid.org/0000-0001-7923-5635
Huiyoon ShinGenome & Health Big Data Laboratory, Seoul National University, Seoul, South Korea.
Bo Young NamInstitute of Kidney Disease Research, College of Medicine, Yonsei University, Seoul, South Korea.
Jimin ParkInstitute of Kidney Disease Research, College of Medicine, Yonsei University, Seoul, South Korea.
Tae-Hyun YooInstitute of Kidney Disease Research, College of Medicine, Yonsei University, Seoul, South Korea.
Gyuri KimInstitute of Kidney Disease Research, College of Medicine, Yonsei University, Seoul, South Korea.
Pureunchowon LeeInstitute of Kidney Disease Research, College of Medicine, Yonsei University, Seoul, South Korea.
Jung Tak ParkInstitute of Kidney Disease Research, College of Medicine, Yonsei University, Seoul, South Korea. jtpark@yuhs.ac.ORCID http://orcid.org/0000-0002-2325-8982
Yonsei University · KRSeoul National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Kidney tubular cell death induced by transforming growth factor-β1 (TGF-β1) is known to contribute to diabetic nephropathy, a major complication of diabetes. Caspase-3-dependent apoptosis and caspase-1-dependent pyroptosis are also involved in tubular cell death under diabetic conditions. Recently, ferroptosis, an atypical form of iron-dependent cell death, was reported to cause kidney disease, including acute kidney injury. Ferroptosis is primed by lipid peroxide accumulation through the cystine/glutamate antiporter system X

Indexed as

FerroptosisAdolescentAdultAgedAmino Acid Transport SystemsAmino Acid Transport Systems, AcidicAmino Acid Transport System y+AnimalsCell LineDiabetes Mellitus, ExperimentalDiabetic NephropathiesFemaleGlutathioneHumansKidney Tubules, ProximalLipid PeroxidationAmino Acid Transport SystemsAmino Acid Transport Systems, AcidicAmino Acid Transport System y+Glutathioneglutathione peroxidase 4, mouseglutathione peroxidase 4, ratPhospholipid Hydroperoxide Glutathione PeroxidaseSLC7A11 protein, humanSlc7a11 protein, mouseSlc7a11 protein, ratTransforming Growth Factor beta1

Identifiers

PMID33558472
PMCPMC7870666
OpenAlexW3126428861

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.