Evidence map›Paper›PMID 33558454›Full record

ArticleSignal transduction and targeted therapy2021

Inhibition of cystathionine β-synthase promotes apoptosis and reduces cell proliferation in chronic myeloid leukemia.

Dan Wang, Huan Yang, Yun Zhang, Rong Hu, Dongjie Hu, Qunxian Wang, Yannan Liu, Mingjing Liu, Zijun Meng, Weihui Zhou and 1 more

Open access · goldAbstract read
In one paragraph

Article in Signal transduction and targeted therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 37 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. A Bioluminescent Probe for HACS bio & med chem Au · 2025
    Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. CystathionineOxidative medicine and cellular longevity · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Dan Wang *Chongqing City Key Lab of Translational Medical Research in Cognitive Development and Learning and Memory Disorders; Ministry of Education Key Laboratory of Child Development and Disorders; National Clinical Research Center for Child Health and Disorders (Chongqing); and Department of Neurology, Children's Hospital of Chongqing Medical University, 400014, Chongqing, China.
Huan Yang *Chongqing City Key Lab of Translational Medical Research in Cognitive Development and Learning and Memory Disorders; Ministry of Education Key Laboratory of Child Development and Disorders; National Clinical Research Center for Child Health and Disorders (Chongqing); and Department of Neurology, Children's Hospital of Chongqing Medical University, 400014, Chongqing, China.
Yun Zhang *Townsend Family Laboratories, Department of Psychiatry, The University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, V6T 1Z3, Canada.
Rong HuChongqing City Key Lab of Translational Medical Research in Cognitive Development and Learning and Memory Disorders; Ministry of Education Key Laboratory of Child Development and Disorders; National Clinical Research Center for Child Health and Disorders (Chongqing); and Department of Neurology, Children's Hospital of Chongqing Medical University, 400014, Chongqing, China.
Dongjie HuChongqing City Key Lab of Translational Medical Research in Cognitive Development and Learning and Memory Disorders; Ministry of Education Key Laboratory of Child Development and Disorders; National Clinical Research Center for Child Health and Disorders (Chongqing); and Department of Neurology, Children's Hospital of Chongqing Medical University, 400014, Chongqing, China.
Qunxian WangChongqing City Key Lab of Translational Medical Research in Cognitive Development and Learning and Memory Disorders; Ministry of Education Key Laboratory of Child Development and Disorders; National Clinical Research Center for Child Health and Disorders (Chongqing); and Department of Neurology, Children's Hospital of Chongqing Medical University, 400014, Chongqing, China.
Yannan LiuChongqing City Key Lab of Translational Medical Research in Cognitive Development and Learning and Memory Disorders; Ministry of Education Key Laboratory of Child Development and Disorders; National Clinical Research Center for Child Health and Disorders (Chongqing); and Department of Neurology, Children's Hospital of Chongqing Medical University, 400014, Chongqing, China.
Mingjing LiuChongqing City Key Lab of Translational Medical Research in Cognitive Development and Learning and Memory Disorders; Ministry of Education Key Laboratory of Child Development and Disorders; National Clinical Research Center for Child Health and Disorders (Chongqing); and Department of Neurology, Children's Hospital of Chongqing Medical University, 400014, Chongqing, China.
Zijun MengChongqing City Key Lab of Translational Medical Research in Cognitive Development and Learning and Memory Disorders; Ministry of Education Key Laboratory of Child Development and Disorders; National Clinical Research Center for Child Health and Disorders (Chongqing); and Department of Neurology, Children's Hospital of Chongqing Medical University, 400014, Chongqing, China.
Weihui ZhouChongqing City Key Lab of Translational Medical Research in Cognitive Development and Learning and Memory Disorders; Ministry of Education Key Laboratory of Child Development and Disorders; National Clinical Research Center for Child Health and Disorders (Chongqing); and Department of Neurology, Children's Hospital of Chongqing Medical University, 400014, Chongqing, China.
Weihong SongChongqing City Key Lab of Translational Medical Research in Cognitive Development and Learning and Memory Disorders; Ministry of Education Key Laboratory of Child Development and Disorders; National Clinical Research Center for Child Health and Disorders (Chongqing); and Department of Neurology, Children's Hospital of Chongqing Medical University, 400014, Chongqing, China. weihong@mail.ubc.ca.ORCID http://orcid.org/0000-0001-9928-889X
National Clinical Research · USUniversity of British Columbia · CAUniversity of British Columbia Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Increased endogenous hydrogen sulfide (H

Indexed as

AnimalsApoptosisBone Marrow CellsCarcinogenesisCell Line, TumorCell ProliferationChildCystathionine beta-SynthaseEnergy MetabolismFemaleHeterograftsHumansHydrogen SulfideLeukemia, Myelogenous, Chronic, BCR-ABL PositiveLeukocytes, MononuclearMaleCystathionine beta-SynthaseHydrogen Sulfide

Identifiers

PMID33558454
PMCPMC7870845
OpenAlexW3128681620

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.