ArticleThe British journal of general practice : the journal of the Royal College of General Practitioners2021
Factors predicting statin prescribing for primary prevention: a historical cohort study.
Article in The British journal of general practice : the journal of the Royal College of General Practitioners, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 6 citations in OpenAlex.
- Trends and inequalities in statin use for the primary and secondary prevention of cardiovascular disease between 2009 and 2021 in England: a series of cross-sectional and cohort studies.BMJ public health · 2026Article
- Cardiovascular risk estimation and statin adherence: a historical cohort study protocol.BJGP open · 2025Article
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5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundInitiation of statins for the primary prevention of cardiovascular disease (CVD) should be based on CVD risk estimates, but their use is suboptimal.
aimTo investigate the factors influencing statin prescribing when clinicians code and do not code estimated CVD risk (QRISK2). DESIGN AND
settingA historical cohort of patients who had lipid tests in a database (IQVIA Medical Research Data) of UK primary care records.
methodThe cohort comprised 686 560 entries (lipid test results) between 2012 and 2016 from 383 416 statin-naive patients without previous CVD. Coded QRISK2 scores were extracted, with variables used in calculating QRISK2 and factors that might influence statin prescribing. If a QRISK2 score was not coded, it was calculated post hoc. The outcome was initiation of a statin within 60 days of the lipid test result.
resultsOf the entries, 146 693 (21.4%) had a coded QRISK2 score. Statins were initiated in 6.6% (95% confidence interval [CI] = 6.4% to 6.7%) of those with coded and 4.1% (95% CI = 4.0% to 4.1%) of uncoded QRISK2 (
conclusionWhen a QRISK2 score is coded, prescribing is more consistent with guidelines. With no QRISK2 score, prescribing is mainly based on total cholesterol. Using QRISK2 is associated with statin prescribing that is more likely to benefit patients. Promoting the routine CVD risk estimation is essential to optimise decision making.
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