Evidence map›Paper›PMID 33558290›Full record

ArticleAntimicrobial agents and chemotherapy2023

Therapeutic potential of coumestan Pks13 inhibitors for tuberculosis.

Shichun Lun, Shiqi Xiao, Wei Zhang, Shuangshuang Wang, Hendra Gunosewoyo, Li-Fang Yu, William R Bishai

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Inhibitors of the Thioesterase Activity ofACS infectious diseases · 2024
    Article
  7. Unlocking Opportunities forACS infectious diseases · 2024
    Review
  8. Review
  9. Article
  10. Tuberculosis: Pathogenesis, Current Treatment Regimens and New Drug Targets.International journal of molecular sciences · 2023
    Review
  11. OvercomingActa pharmaceutica Sinica. B · 2022
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Shichun LunCenter for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Shiqi XiaoCenter for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Wei ZhangShanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, and Shanghai Key Laboratory of Green Chemistry and Chemical Process, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, China.
Shuangshuang WangShanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, and Shanghai Key Laboratory of Green Chemistry and Chemical Process, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, China.
Hendra GunosewoyoSchool of Pharmacy and Biomedical Sciences, Faculty of Health Sciences, Curtin University, Perth, Australia.
Li-Fang YuShanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, and Shanghai Key Laboratory of Green Chemistry and Chemical Process, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, China wbishai1@jhmi.edu lfyu@sat.ecnu.edu.cn.
William R BishaiCenter for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA wbishai1@jhmi.edu lfyu@sat.ecnu.edu.cn.ORCID https://orcid.org/0000-0002-8734-4118
East China Normal University · CNJohns Hopkins University · USCurtin University · AU

Funding

Mycobacterium tuberculosis Survival Regulatory GenesR01AI037856 · NIAID · JOHNS HOPKINS UNIVERSITY · PI BISHAI, WILLIAM RAMSES · 1997 to 2020
$7.2M
Aberrant immune activation in the tuberculosis granuloma: a pivotal role in necrosisR01HL133190 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BISHAI, WILLIAM RAMSES, KRAMNIK, IGOR · 2016 to 2019
$3.0M
NHLBI NIH HHS R01 HL133190NIAID NIH HHS R01 AI037856
6 · The paper itself

Abstract

Polyketide synthase 13 (Pks13) is an important enzyme found in

Identifiers

PMID33558290
PMCPMC8092898
OpenAlexW3128595122

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.