Evidence map›Paper›PMID 33558267›Full record

ArticleDiabetes care2021

Association of Metabolic Phenotypes With Coronary Artery Disease and Cardiovascular Events in Patients With Stable Chest Pain.

Andreas A Kammerlander, Thomas Mayrhofer, Maros Ferencik, Neha J Pagidipati, Julia Karady, Geoffrey S Ginsburg, Michael T Lu, Daniel O Bittner, Stefan B Puchner, Nathan A Bihlmeyer and 6 more

Open access · bronzeAbstract readMulticenter Study
In one paragraph

Article in Diabetes care, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 38 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 3 countries.

Andreas A KammerlanderCardiovascular Imaging Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA akammerlander@mgh.harvard.edu.
Thomas MayrhoferCardiovascular Imaging Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA.ORCID 0000-0002-7632-9879
Maros FerencikCardiovascular Imaging Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Neha J PagidipatiDuke Clinical Research Institute, Duke University School of Medicine, Durham, NC.
Julia KaradyCardiovascular Imaging Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Geoffrey S GinsburgDuke Center for Applied Genomics & Precision Medicine, Duke University School of Medicine, Durham, NC.
Michael T LuCardiovascular Imaging Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Daniel O BittnerCardiovascular Imaging Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Stefan B PuchnerCardiovascular Imaging Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Nathan A BihlmeyerDuke Molecular Physiology Institute, Durham, NC.
Nandini M MeyersohnCardiovascular Imaging Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Hamed EmamiCardiovascular Imaging Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Svati H ShahDuke Clinical Research Institute, Duke University School of Medicine, Durham, NC.
Pamela S DouglasDuke Clinical Research Institute, Duke University School of Medicine, Durham, NC.
Udo Hoffmann
PROMISE Investigators
Harvard University · USDuke University · USDuke Medical Center · US

Funding

PROMISE Trial: Clinical Coordinating CenterR01HL098237 · NHLBI · DUKE UNIVERSITY · PI DOUGLAS, PAMELA SUSAN · 2009 to 2014
$27.3M
REPRIEVE - DCCU01HL123339 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI LU, MICHAEL TSE-YIN, RIBAUDO, HEATHER JANE · 2014 to 2019
$6.0M
PROMISE Trial: SDCCR01HL098236 · NHLBI · DUKE UNIVERSITY · PI LEE, KERRY L · 2009 to 2014
$5.0M
Cardiac MR and CT ResearchT32HL076136 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI NEILAN, TOMAS G · 2004 to 2019
$4.9M
PROMISE Trial: Dx CoreR01HL098305 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI HOFFMANN, UDO · 2009 to 2014
$3.5M
PROMISE Trial: Substudy to Assess for Effective Dose of RadiationR01HL109711 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI EINSTEIN, ANDREW · 2011 to 2015
$2.5M
PROMISE Trial: EQOL Coordinating CenterR01HL098235 · NHLBI · DUKE UNIVERSITY · PI MARK, DANIEL B · 2009 to 2014
$1.6M
Cardiovascular Imaging in Ischemic Heart DiseaseK24HL113128 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI HOFFMANN, UDO · 2012 to 2020
$1.1M
NHLBI NIH HHS K24 HL113128NHLBI NIH HHS R01 HL098235NHLBI NIH HHS R01 HL098236NHLBI NIH HHS R01 HL098237NHLBI NIH HHS R01 HL098305NHLBI NIH HHS R01 HL109711NHLBI NIH HHS T32 HL076136NHLBI NIH HHS U01 HL123339
6 · The paper itself

Abstract

objectiveObesity and metabolic syndrome are associated with major adverse cardiovascular events (MACE). However, whether distinct metabolic phenotypes differ in risk for coronary artery disease (CAD) and MACE is unknown. We sought to determine the association of distinct metabolic phenotypes with CAD and MACE. RESEARCH DESIGN AND

methodsWe included patients from the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) who underwent coronary computed tomography (CT) angiography. Obesity was defined as a BMI ≥30 kg/m

resultsOf 4,381 patients (48.4% male, 60.5 ± 8.1 years of age), 49.4% were metabolically healthy (30.7% MHN and 18.7% MHO) and 50.6% unhealthy (22.3% MUN and 28.4% MUO). MHO had similar coronary CT findings as compared with MHN (severe CAC/CAD and HRP;

conclusionsIn patients with stable chest pain, four metabolic phenotypes exhibit distinctly different CAD characteristics and risk for MACE. Individuals who are metabolically unhealthy despite not being obese were at highest risk in our cohort.

Indexed as

Coronary Artery DiseaseMetabolic SyndromeChest PainFemaleHumansMaleMiddle AgedPhenotypeProspective StudiesRisk Factors

Identifiers

PMID33558267
PMCPMC7985425
OpenAlexW3129047368

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.