Evidence map›Paper›PMID 33558223›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Secretagogin marks amygdaloid PKCδ interneurons and modulates NMDA receptor availability.

Zsófia Hevesi, Dóra Zelena, Roman A Romanov, János Hanics, Attila Ignácz, Alice Zambon, Daniela D Pollak, Dávid Lendvai, Katalin Schlett, Miklós Palkovits and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Neuronal activity modulates the expression of secretagogin, a CaActa physiologica (Oxford, England) · 2025
    Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 3 countries.

Zsófia HevesiSE-NAP Research Group of Experimental Neuroanatomy and Developmental Biology, Hungarian Academy of Sciences, H-1094 Budapest, Hungary.ORCID 0000-0002-9341-9892
Dóra ZelenaBehavioral Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1083 Budapest, Hungary.
Roman A RomanovDepartment of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, A-1090 Vienna, Austria.
János HanicsSE-NAP Research Group of Experimental Neuroanatomy and Developmental Biology, Hungarian Academy of Sciences, H-1094 Budapest, Hungary.
Attila IgnáczNeuronal Cell Biology Research Group, Department of Physiology and Neurobiology, Eötvös Loránd University, H-1117 Budapest, Hungary.ORCID 0000-0002-2930-1582
Alice ZambonDepartment of Neurophysiology and Neuropharmacology, Medical University of Vienna, A-1090 Vienna, Austria.
Daniela D PollakDepartment of Neurophysiology and Neuropharmacology, Medical University of Vienna, A-1090 Vienna, Austria.ORCID 0000-0002-9584-6257
Dávid LendvaiDepartment of Anatomy, Semmelweis University, H-1094 Budapest, Hungary.
Katalin SchlettNeuronal Cell Biology Research Group, Department of Physiology and Neurobiology, Eötvös Loránd University, H-1117 Budapest, Hungary.ORCID 0000-0001-9265-4236
Miklós PalkovitsHuman Brain Tissue Bank and Laboratory, Semmelweis University, H-1094 Budapest, Hungary.ORCID 0000-0003-0578-0387
Tibor HarkanyDepartment of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, A-1090 Vienna, Austria.
Tomas G M HökfeltDepartment of Neuroscience, Biomedicum D0776, Karolinska Institutet, SE-17165 Solna, Sweden Tomas.Hokfelt@ki.se alpar.alan@med.semmelweis-univ.hu.
Alán AlpárSE-NAP Research Group of Experimental Neuroanatomy and Developmental Biology, Hungarian Academy of Sciences, H-1094 Budapest, Hungary; Tomas.Hokfelt@ki.se alpar.alan@med.semmelweis-univ.hu.
Semmelweis University · HUMedical University of Vienna · ATEötvös Loránd University · HUKarolinska Institutet · SEHUN-REN Institute of Experimental Medicine · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The perception of and response to danger is critical for an individual's survival and is encoded by subcortical neurocircuits. The amygdaloid complex is the primary neuronal site that initiates bodily reactions upon external threat with local-circuit interneurons scaling output to effector pathways. Here, we categorize central amygdala neurons that express secretagogin (Scgn), a Ca

Indexed as

AmygdalaAnimalsAvoidance LearningCell Line, TumorCells, CulturedFearFemaleHumansInterneuronsMaleProtein Kinase C-deltaProtein TransportRatsRats, WistarReceptors, N-Methyl-D-AspartateSecretagoginsProtein Kinase C-deltaReceptors, N-Methyl-D-AspartateSecretagoginsassociative learningcalcium-binding proteinfear conditioninglimbic system

Identifiers

PMID33558223
PMCPMC7896286
OpenAlexW3126551402

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.