ArticleeLife2021
Epidemiological transition to mortality and refracture following an initial fracture.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The impact of a fracture liaison service for patients with femoral fractures on subsequent fractures and mortality: focusing on systematic literature review and metaanalysis.Archives of osteoporosis · 2025Pooled it
- Comparisons of phantom-based and phantomless QCT bone mineral density for predicting subsequent fractures.Bone & joint research · 2026Article
- [Osteoporosis-a plea for consistent diagnosis and treatment-also in men : Contra paradox: high prevalence rate, low treatment rate].Innere Medizin (Heidelberg, Germany) · 2026Review
- Opioid Use After Hip Fracture and Subsequent Fracture Outcomes: A Self-Controlled Case Series Design.Pharmacoepidemiology and drug safety · 2025Article
- Fracture risk assessment in the presence of competing risk of death.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024Article
- Clinical Outcomes and Cost-Effectiveness of Osteoporosis Screening With Dual-Energy X-ray Absorptiometry.Korean journal of radiology · 2023Article
- BONEcheck: A digital tool for personalized bone health assessment.Osteoporosis and sarcopenia · 2023Article
- All-cause mortality risk in older patients with femoral neck fracture.BMC musculoskeletal disorders · 2022Article
- Article
- All-cause mortality risk in aged femoral intertrochanteric fracture patients.Journal of orthopaedic surgery and research · 2021Article
- Bone age is not just for kids.eLife · 2021Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study sought to redefine the concept of fracture risk that includes refracture and mortality, and to transform the risk into "skeletal age". We analysed data obtained from 3521 women and men aged 60 years and older, whose fracture incidence, mortality, and bone mineral density (BMD) have been monitored since 1989. During the 20-year follow-up period, among 632 women and 184 men with a first incident fracture, the risk of sustaining a second fracture was higher in women (36%) than in men (22%), but mortality risk was higher in men (41%) than in women (25%). The increased risk of mortality was not only present with an initial fracture, but was accelerated with refractures. Key predictors of post-fracture mortality were male gender (hazard ratio [HR] 2.4; 95% CI, 1.79-3.21), advancing age (HR 1.67; 1.53-1.83), and lower femoral neck BMD (HR 1.16; 1.01-1.33). A 70-year-old man with a fracture is predicted to have a skeletal age of 75. These results were incorporated into a prediction model to aid patient-doctor discussion about fracture vulnerability and treatment decisions.
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Registered trials
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