ArticleInfection control and hospital epidemiology2022
Hydrogen peroxide vapor decontamination of N95 respirators for reuse.
Article in Infection control and hospital epidemiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Mask decontamination methods (model N95) for respiratory protection: a rapid review.Systematic reviews · 2021Pooled it
- Outdoor disinfectant sprays for the prevention of COVID-19: Are they safe for the environment?The Science of the total environment · 2021Pooled it
- Decontamination and reuse of surgical masks and N95 filtering facepiece respirators during the COVID-19 pandemic: A systematic review.Infection control and hospital epidemiology · 2021Pooled it
- Decontamination and reuse of N95 filtering facemask respirators: A systematic review of the literature.American journal of infection control · 2020Pooled it
- Efficacy and safety of disinfectants for decontamination of N95 and SN95 filtering facepiece respirators: a systematic review.The Journal of hospital infection · 2020Pooled it
- Exploring options for reprocessing of N95 Filtering Facepiece Respirators (N95-FFRs) amidst COVID-19 pandemic: A systematic review.PloS one · 2020Pooled it
- Hybrid Mortar Composites Incorporating Oyster Shell Filler and Recycled Fibers from Disposable Masks.Materials (Basel, Switzerland) · 2025Article
- Use of Hydrogen Peroxide Vapour for Microbiological Disinfection in Hospital Environments: A Review.Bioengineering (Basel, Switzerland) · 2024Review
- Performance evaluation of an electrostatic precipitator with a copper plate using an aerosolized SARS-CoV-2 surrogate (bacteriophage phi 6).Environmental technology & innovation · 2023Article
- Evaluation of disinfection methods for personal protective equipment (PPE) items for reuse during a pandemic.PloS one · 2023Article
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- Mask disinfection using atmospheric pressure cold plasma.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2022Article
- Dry Heat as a Potential Decontamination Method on the Filtration Efficiency of Filtering Facepiece Respirators.International journal of environmental research and public health · 2022Article
- Hydrogen Peroxide Vapor Decontamination of Hazard Group 3 Bacteria and Viruses in a Biosafety Level 3 Laboratory.Applied biosafety : journal of the American Biological Safety Association · 2022Article
- Review of aerosolized hydrogen peroxide, vaporized hydrogen peroxide, and hydrogen peroxide gas plasma in the decontamination of filtering facepiece respirators.American journal of infection control · 2022Review
- Masks for COVID-19.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Review
- Stakeholder perspectives on scaling up medical device reprocessing: A qualitative study.PloS one · 2022Article
- Safety and structural integrity of N95/PFF2 respirators decontamination.American journal of infection control · 2021Article
- A pre-systematic review on the use of masks as a protection material for SARS-COV-2 during the COVID-19 pandemic.International journal of clinical practice · 2021Review
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
objectiveThe coronavirus disease 2019 (COVID-19) pandemic has led to global shortages of N95 respirators. Reprocessing of used N95 respirators may provide a higher filtration crisis alternative, but whether effective sterilization can be achieved for a virus without impairing respirator function remains unknown. We evaluated the viricidal efficacy of Bioquell vaporized hydrogen peroxide (VHP) on contaminated N95 respirators and tested the particulate particle penetration and inhalation and exhalation resistance of respirators after multiple cycles of VHP.
methodsFor this study, 3M 1870 N95 respirators were contaminated with 3 aerosolized bacteriophages: T1, T7, and Pseudomonas phage phi-6 followed by 1 cycle of VHP decontamination using a BQ-50 system. Additionally, new and unused respirators were sent to an independent laboratory for particulate filter penetration testing and inhalation and exhalation resistance after 3 and 5 cycles of VHP.
resultsA single VHP cycle resulted in complete eradication of bacteriophage from respirators (limit of detection 10 PFU). Respirators showed acceptable limits for inhalation/exhalation resistance after 3 and 5 cycles of VHP. Respirators demonstrated a filtration efficiency >99 % after 3 cycles, but filtration efficiency fell below 95% after 5 cycles of HPV.
conclusionBioquell VHP demonstrated high viricidal activity for N95 respirators inoculated with aerosolized bacteriophages. Bioquell technology can be scaled for simultaneous decontamination of a large number of used but otherwise intact respirators. Reprocessing should be limited to 3 cycles due to concerns both about impact of clinical wear and tear on fit, and to decrement in filtration after 3 cycles.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.