Evidence map›Paper›PMID 33557807›Full record

ArticleJournal of nanobiotechnology2021

Thermo-responsive polymer encapsulated gold nanorods for single continuous wave laser-induced photodynamic/photothermal tumour therapy.

Beilei Gong, Yuanbing Shen, Huiyan Li, Xiaojun Li, Xia Huan, Jihong Zhou, Yuqing Chen, Jian Wu, Wei Li

Open access · goldAbstract read
In one paragraph

Article in Journal of nanobiotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
5.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 73 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Beilei Gong *Department of Respiratory Disease, The First Affiliated Hospital of Bengbu Medical College, Bengbu, 233004, China.
Yuanbing Shen *Department of Respiratory Disease, The First Affiliated Hospital of Bengbu Medical College, Bengbu, 233004, China.
Huiyan Li *Department of Medical Microbiology, MOE/NHC/CAMS Key Laboratory of Medical Molecular Virology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.
Xiaojun LiDepartment of Thoracic Surgery, the First Affiliated Hospital of Bengbu Medical College, 233004, Bengbu, China.
Xia HuanDepartment of Respiratory Disease, People's Hospital of Shannan, Shannan, 856000, Tibet, China.
Jihong ZhouAnhui Province Key Laboratory of Translational Cancer Research, Bengbu, 233003, Anhui, China.
Yuqing ChenDepartment of Respiratory Disease, The First Affiliated Hospital of Bengbu Medical College, Bengbu, 233004, China.
Jian WuDepartment of Medical Microbiology, MOE/NHC/CAMS Key Laboratory of Medical Molecular Virology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China. jian.wu@fudan.edu.cn.
Wei LiDepartment of Respiratory Disease, The First Affiliated Hospital of Bengbu Medical College, Bengbu, 233004, China. bbmcliwei@126.com.
First Affiliated Hospital of Bengbu Medical College · CNFudan University · CN

Funding

Key Laboratory of Microbial Resources and Drug Development in Guizhou Province (CN) gxbjZD16Key Research and Development Projects in Anhui Province for A 201904a07020079Key Research and Development Projects in Anhui Province for B 202004J07020010the National Natural Science Foundation of Tibet XZ2017ZR-ZY033
6 · The paper itself

Abstract

Owing to strong and tunable surface plasmon resonance (SPR) effect and good biocompatibility, gold nanoparticles have been suggested to be a versatile platform for a broad range of biomedical applications. In this study, a new nanoplatform of thermo-responsive polymer encapsulated gold nanorods incorporating indocyanine green (ICG) was designed to couple the photothermal properties of gold nanorods (AuNRs) and the photodynamic properties of ICG to enhance the photodynamic/photothermal combination therapy (PDT/PTT). In addition to the significantly increased payload and enhancing photostability of ICG, the polymer shell in the nanoplatform also has thermo-responsive characteristics that can control the release of drugs at tumour sites upon the laser irradiation. On the basis of these improvements, the nanoplatform strongly increased drug aggregation at the tumour site and improved the photothermal/photodynamic therapeutic efficacy. These results suggest that this nanoplatform would be a great potential system for tumour imaging and antitumour therapy.

Indexed as

A549 CellsAnimalsAntineoplastic AgentsCell SurvivalCombined Modality TherapyDrug LiberationGoldHumansHyperthermia, InducedIndocyanine GreenLasersMetal NanoparticlesMiceNanocompositesNanotubesPhotochemotherapyAntineoplastic AgentsGoldIndocyanine GreenPolymersGold nanorodsPhotodynamic therapyPhotothermal therapyThermoresponsive

Identifiers

PMID33557807
PMCPMC7869504
OpenAlexW3127406776

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.