Evidence map›Paper›PMID 33557802›Full record

ArticleBMC pulmonary medicine2021

Gastritis and gastroesophageal reflux disease are strongly associated with non-allergic nasal disorders.

Eliana Finocchio, Francesca Locatelli, Francesca Sanna, Roberta Vesentini, Pierpaolo Marchetti, Gianluca Spiteri, Leonardo Antonicelli, Salvatore Battaglia, Roberto Bono, Angelo Guido Corsico and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pulmonary medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Causal analysis between gastroesophageal reflux disease and chronic rhinosinusitis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024
    Article
  4. Review
  5. Detection of Helicobacter Pylori in Nasal Polyps: An Epidemiological Study.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2023
    Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 1 country.

Eliana FinocchioSection of Epidemiology and Medical Statistics, Department of Diagnostic and Public Health, University of Verona, Strada Le Grazie, 8, 37134, Verona, Italy.
Francesca LocatelliSection of Epidemiology and Medical Statistics, Department of Diagnostic and Public Health, University of Verona, Strada Le Grazie, 8, 37134, Verona, Italy.
Francesca SannaSection of Epidemiology and Medical Statistics, Department of Diagnostic and Public Health, University of Verona, Strada Le Grazie, 8, 37134, Verona, Italy.
Roberta VesentiniSection of Epidemiology and Medical Statistics, Department of Diagnostic and Public Health, University of Verona, Strada Le Grazie, 8, 37134, Verona, Italy.
Pierpaolo MarchettiSection of Epidemiology and Medical Statistics, Department of Diagnostic and Public Health, University of Verona, Strada Le Grazie, 8, 37134, Verona, Italy.
Gianluca SpiteriUnit of Occupational Medicine, Department of Diagnostics and Public Health, University of Verona, P.le L.A. Scuro 10, 37134, Verona, Italy.
Leonardo AntonicelliDepartment of Internal Medicine Ospedali Riuniti Ancona, Via Conca, 71, 60126, Ancona, Italy.
Salvatore BattagliaUniversity of Palermo, Piazza Marina, 61, 90133, Palermo, Italy.
Roberto BonoDepartment of Public Health and Pediatrics, University of Torino, Via Santena 5 bis, 10126, Torino, Italy.
Angelo Guido CorsicoDepartment of Internal Medicine and Medical Therapy, University of Pavia, Palazzo Botta, 10, 27100, Pavia, Italy.
Marcello FerrariUnit of Respiratory Diseases, Department of Medicine, University of Verona, P.le L.A. Scuro 10, 37134, Verona, Italy.
Nicola MurgiaSection of Occupational Medicine, Respiratory Diseases and Toxicology, University of Perugia, Piazza dell'Università, 1, 06123, Perugia, Italy.
Pietro PirinaDepartment of Clinical, Surgical and Experimental Sciences, University of Sassari, Piazza Università, 21, 07100, Sassari, Italy.
Mario OlivieriUnit of Occupational Medicine, Department of Diagnostics and Public Health, University of Verona, P.le L.A. Scuro 10, 37134, Verona, Italy.
Giuseppe VerlatoSection of Epidemiology and Medical Statistics, Department of Diagnostic and Public Health, University of Verona, Strada Le Grazie, 8, 37134, Verona, Italy. giuseppe.verlato@univr.it.ORCID http://orcid.org/0000-0001-5262-8818
University of Verona · ITOspedali Riuniti di Ancona · ITUniversity of Palermo · ITUniversity of Pavia · ITUniversity of Perugia · ITUniversity of Sassari · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGastroesophageal reflux disease (GERD) has been reported to be significantly associated with chronic rhinosinusitis, but the strength of the association is still debated.

aimsTo evaluate the strength of the association between gastritis/GERD and non-allergic rhinitis (NAR)/allergic rhinitis (AR)/sinusitis.

methodsWe investigated 2887 subjects aged 20-84 years, who underwent a clinical visit in seven Italian centres (Ancona, Palermo, Pavia, Terni, Sassari, Torino, Verona) within the study on Gene Environment Interactions in Respiratory Diseases, a population-based multicase-control study between 2008 and 2014. Subjects were asked if they had doctor-diagnosed "gastritis or stomach ulcer (confirmed by gastroscopy)" or "gastroesophageal reflux disease, hiatal hernia or esophagitis". The association between NAR/AR/sinusitis and either gastritis or GERD was evaluated through relative risk ratios (RRR) by multinomial logistic regression.

resultsThe prevalence of gastritis/GERD increased from subjects without nasal disturbances (22.8% = 323/1414) to subjects with AR (25.8% = 152/590) and further to subjects with NAR (36.7% = 69/188) or sinusitis (39.9% = 276/691). When adjusting for centre, sex, age, education level, BMI, smoking habits and alcohol intake, the combination of gastritis and GERD was associated with a four-fold increase in the risk of NAR (RRR = 3.80, 95% CI 2.56-5.62) and sinusitis (RRR = 3.70, 2.62-5.23) with respect to controls, and with a much smaller increase in the risk of AR (RRR = 1.79, 1.37-2.35)..

conclusionThe study confirmed the association between gastritis/GERD and nasal disturbances, which is stronger for NAR and sinusitis than for AR.

Indexed as

AdultAgedAged, 80 and overChronic DiseaseFemaleGastritisGastroesophageal RefluxHumansItalyMaleMiddle AgedPrevalenceRhinitisRhinitis, AllergicSinusitisYoung AdultAllergic rhinitisGastrititsGastroesophageal reflux diseaseNon-allergic rhinitisSinusitis

Identifiers

PMID33557802
PMCPMC7869508
OpenAlexW3127327367

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.