Evidence map›Paper›PMID 33557785›Full record

ArticleBMC infectious diseases2021

Renal dysfunction and prognosis of COVID-19 patients: a hospital-based retrospective cohort study.

Hui-Xian Xiang, Jun Fei, Ying Xiang, Zheng Xu, Ling Zheng, Xiu-Yong Li, Lin Fu, Hui Zhao

Open access · goldAbstract read
In one paragraph

Article in BMC infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 2 pooled it
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.

  1. Pooled it
  2. Prognostic Performance of Cystatin C in COVID-19: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022
    Pooled it
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  12. Study of Biochemical Parameters as Predictors for Need of Invasive Ventilation in Severely Ill COVID-19 Patients.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2023
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  20. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Hui-Xian Xiang *Second Affiliated Hospital, Anhui Medical University, Furong Road no 678, Hefei, 230601, Anhui Province, China.
Jun Fei *Second Affiliated Hospital, Anhui Medical University, Furong Road no 678, Hefei, 230601, Anhui Province, China.
Ying Xiang *Second Affiliated Hospital, Anhui Medical University, Furong Road no 678, Hefei, 230601, Anhui Province, China.
Zheng XuSecond Affiliated Hospital, Anhui Medical University, Furong Road no 678, Hefei, 230601, Anhui Province, China.
Ling ZhengSecond Affiliated Hospital, Anhui Medical University, Furong Road no 678, Hefei, 230601, Anhui Province, China.
Xiu-Yong LiSecond People's Hospital of Fuyang City, Fuyang, 236015, Anhui Province, China.
Lin FuSecond Affiliated Hospital, Anhui Medical University, Furong Road no 678, Hefei, 230601, Anhui Province, China. fulindev@126.com.
Hui ZhaoSecond Affiliated Hospital, Anhui Medical University, Furong Road no 678, Hefei, 230601, Anhui Province, China. zhaohuichenxi@126.com.
Anhui Medical University · CNSecond Hospital of Anhui Medical University · CNFuyang Second People's Hospital · CN

Funding

National Natural Science Foundation Incubation Program of the Second Affiliated Hospital of Anhui Medical University 2019GQFY06
6 · The paper itself

Abstract

introductionIncreasing evidence indicate that coronavirus disease 2019 (COVID-19) is companied by renal dysfunction. However, the association of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2)-induced renal dysfunction with prognosis remains obscure. MATERIALS AND

methodsAll 154 patients with COVID-19 were recruited from the Second People's Hospital of Fuyang City in Anhui, China. Demographic characteristics and laboratory data were extracted. Renal dysfunction was evaluated and its prognosis was followed up based on a retrospective cohort study.

resultsThere were 125 (81.2%) mild and 29 (18.8%) severe cases in 154 COVID-19 patients. On admission, 16 (10.4%) subjects were accompanied with renal dysfunction. Serum creatinine and cystatin C were increased and estimated glomerular filtration rate (eGFR) was decreased in severe patients compared with those in mild patients. Renal dysfunction was more prevalent in severe patients. Using multivariate logistic regression, we found that male gender, older age and hypertension were three importantly independent risk factors for renal dysfunction in COVID-19 patients. Follow-up study found that at least one renal function marker of 3.33% patients remained abnormal in 2 weeks after discharge.

conclusionMale elderly COVID-19 patients with hypertension elevates the risk of renal dysfunction. SARS-CoV-2-induced renal dysfunction are not fully recovered in 2 weeks after discharge.

Indexed as

AdultAgedAge FactorsChinaCOVID-19CreatinineFemaleFollow-Up StudiesGlomerular Filtration RateHumansHypertensionKidneyKidney DiseasesKidney Function TestsMaleMiddle AgedCreatinineCoronavirus disease 2019PrognosisRenal dysfunctionSevere acute respiratory syndrome coronavirus-2

Identifiers

PMID33557785
PMCPMC7868870
OpenAlexW3116754365

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.