Observational studyBMC infectious diseases2021
The association between clinical laboratory data and chest CT findings explains disease severity in a large Italian cohort of COVID-19 patients.
Observational study in BMC infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The trial behind it
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Trial
- Comparison of Severe COVID-19 Outcomes in Vaccinated and Unvaccinated Patients, with and Without Diabetes Mellitus in a Romanian Tertiary Healthcare Pneumology Hospital-A Retrospective Study.International journal of molecular sciences · 2026Article
- Accurate screening of patients with diabetes based on physical examination: pancreas imaging features from chest CT and laboratory data.Frontiers in endocrinology · 2025Article
- Tocilizumab demonstrates superiority in decreasing C-reactive protein levels in hospitalized COVID-19 patients, compared to standard care treatment alone.Microbiology spectrum · 2024Observational
- Association between volume of lung damage and endoplasmic reticulum stress expression among severe COVID-19 ICU patients.Frontiers in medicine · 2024Article
- Novel machine-learning analysis of SARS-CoV-2 infection in a subclinical nonhuman primate model using radiomics and blood biomarkers.Scientific reports · 2023Article
- Lactate dehydrogenase and PaO2/FiO2 ratio at admission helps to predict CT score in patients with COVID-19: An observational study.Journal of infection and public health · 2023Observational
- COVID-19 therapy optimization by AI-driven biomechanical simulations.European physical journal plus · 2023Article
- Inflammatory burden and persistent CT lung abnormalities in COVID-19 patients.Scientific reports · 2022Article
- Chest CT severity score: assessment of COVID‑19 severity and short-term prognosis in hospitalized Iranian patients.Wiener medizinische Wochenschrift (1946) · 2022Article
- A Review of Routine Laboratory Biomarkers for the Detection of Severe COVID-19 Disease.International journal of analytical chemistry · 2022Review
- Article
- Article
- Article
- The Impact ofMicroorganisms · 2021Review
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLaboratory data and computed tomography (CT) have been used during the COVID-19 pandemic, mainly to determine patient prognosis and guide clinical management. The aim of this study was to evaluate the association between CT findings and laboratory data in a cohort of COVID-19 patients.
methodsThis was an observational cross-sectional study including consecutive patients presenting to the Reggio Emilia (Italy) province emergency rooms for suspected COVID-19 for one month during the outbreak peak, who underwent chest CT scan and laboratory testing at presentation and resulted positive for SARS-CoV-2.
resultsIncluded were 866 patients. Total leukocytes, neutrophils, C-reactive protein (CRP), creatinine, AST, ALT and LDH increase with worsening parenchymal involvement; an increase in platelets was appreciable with the highest burden of lung involvement. A decrease in lymphocyte counts paralleled worsening parenchymal extension, along with reduced arterial oxygen partial pressure and saturation. After correcting for parenchymal extension, ground-glass opacities were associated with reduced platelets and increased procalcitonin, consolidation with increased CRP and reduced oxygen saturation.
conclusionsPulmonary lesions induced by SARS-CoV-2 infection were associated with raised inflammatory response, impaired gas exchange and end-organ damage. These data suggest that lung lesions probably exert a central role in COVID-19 pathogenesis and clinical presentation.
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