ArticleBMC plant biology2021
Genome-wide analysis of the apple CaCA superfamily reveals that MdCAX proteins are involved in the abiotic stress response as calcium transporters.
Article in BMC plant biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Population Genomics of Almond (Prunus dulcis) Reveals Region-Specific Selection and a Complex History of Domestication.Molecular ecology · 2026Article
- Regulatory insights underlying apple to cold stress.Horticulture research · 2026Article
- Genome-Wide Analysis ofInternational journal of molecular sciences · 2026Article
- Identification of the cation/H+ exchanger genes in peanut and functional analysis ofFrontiers in plant science · 2026Article
- CAX1 beyond calcium transport: evidence for a transport-independent regulatory module in plants.Frontiers in plant science · 2026Review
- A modular fragment of Arabidopsis cation exchanger 1 (CAX1) reveals structural constraints on assembly.Plant molecular biology · 2025Article
- Evolution and diversification of CaBMC plant biology · 2025Article
- Genome-wide identification and expression profiling of MYB transcription factors in Artemisia argyi.BMC genomics · 2025Article
- Evolutionary dynamics of the calcium/cation antiporter superfamily in Brassicaceae: codon usage, selection pressure, andFrontiers in plant science · 2025Article
- Transcriptional Regulation of SugarCane Response toJournal of agricultural and food chemistry · 2024Article
- Functional differentiation and genetic diversity of rice cation exchanger (CAX) genes and their potential use in rice improvement.Scientific reports · 2024Article
- Is calcium deficiency the real cause of bitter pit? A review.Frontiers in plant science · 2024Review
- Genome-Wide Identification ofGenes · 2023Article
- CaCommunications biology · 2023Article
- MdbHLH4 negatively regulates apple cold tolerance by inhibiting MdCBF1/3 expression and promoting MdCAX3L-2 expression.Plant physiology · 2023Article
- Functional identification of the calcineurin B-like protein PavCBL4 in modulating salt tolerance in sweet cherry.Frontiers in plant science · 2023Article
- Calcium channels and transporters: Roles in response to biotic and abiotic stresses.Frontiers in plant science · 2022Review
- Genome-Wide Investigation of theFrontiers in plant science · 2022Article
- Genome-Wide Analysis of the Apple CBL Family Reveals That Mdcbl10.1 Functions Positively in Modulating Apple Salt Tolerance.International journal of molecular sciences · 2021Article
- Cation/CaFrontiers in plant science · 2021Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundCalcium (Ca
resultsHere, we identified 21 CaCA family proteins in apple for the first time. Phylogenetic and gene structure analysis, as well as prediction of conserved motifs, suggested that these proteins could be classified into four groups: CAX, CCX, NCL, and MHX. Expression analysis showed that the 10 MdCAX genes we cloned strongly responded to calcium and abiotic stress treatments. Collinearity analysis and characterisation of calcium transport capacity resulted in the identification of a pair of segmental duplication genes: MdCAX3L-1 and MdCAX3L-2; MdCAX3L-2 showed strong calcium transport capacity, whereas MdCAX3L-1 showed no calcium transport capacity. Yeast two-hybrid (Y2H) assays showed that these two proteins could interact with each other. The high sequence similarity (94.6%) makes them a good model for studying the crucial residues and structural basis of the calcium transport of CAX proteins. Prediction of the protein interaction network revealed several proteins that may interact with CAX proteins and play important roles in plant stress responses, such as SOS2, CXIP1, MHX, NRAMP3, and MTP8.
conclusionsOur analysis indicated that MdCAX proteins have strong calcium transport capacity and are involved in the abiotic stress response in apple. These findings provide new insight and rich resources for future studies of MdCAX proteins in apple.
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