Evidence map›Paper›PMID 33557648›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2021

Design, synthesis, and evaluation of novel coumarin-dithiocarbamate derivatives (IDs) as anti-colorectal cancer agents.

Heping Zhu, Shilong Ying, Bingluo Zhou, Xinyang Hu, Xiao Liang, Wangyu Li, Dungai Wang, Hongchuan Jin, Yuanjiang Pan

Open access · goldAbstract read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Coumarin-Dithiocarbamate Derivatives as Biological Agents.International journal of molecular sciences · 2025
    Review
  2. Characterization of the Antiproliferative and Antimetastatic Properties ofInternational journal of molecular sciences · 2025
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Heping ZhuDepartment of Chemistry, Zhejiang University, Hangzhou, P. R. China.
Shilong YingLaboratory of Cancer Biology, Key Lab of Biotherapy in Zhejiang, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou, P. R. China.
Bingluo ZhouLaboratory of Cancer Biology, Key Lab of Biotherapy in Zhejiang, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou, P. R. China.
Xinyang HuLaboratory of Cancer Biology, Key Lab of Biotherapy in Zhejiang, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou, P. R. China.
Xiao LiangDepartment of Chemistry, Zhejiang University, Hangzhou, P. R. China.
Wangyu LiDepartment of Chemistry, Zhejiang University, Hangzhou, P. R. China.
Dungai WangDepartment of Chemistry, Zhejiang University, Hangzhou, P. R. China.
Hongchuan JinLaboratory of Cancer Biology, Key Lab of Biotherapy in Zhejiang, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou, P. R. China.ORCID https://orcid.org/0000-0002-6697-3097
Yuanjiang PanDepartment of Chemistry, Zhejiang University, Hangzhou, P. R. China.ORCID https://orcid.org/0000-0003-2900-2600
Zhejiang University · CNSir Run Run Shaw Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colorectal cancer (CRC) is a common malignant tumour of human digestive tract. The high mortality rate of CRC is closely related to the limitations of existing treatments. Thus, there is an urgent need to search for new anti-CRC agents. In this work, twenty novel coumarin-dithiocarbamate derivatives (

Indexed as

Drug DesignAntineoplastic AgentsApoptosisBromodomain Containing ProteinsCell Cycle ProteinsCell ProliferationCells, CulturedCell SurvivalColorectal NeoplasmsCoumarinsDose-Response Relationship, DrugDrug Screening Assays, AntitumorHumansMolecular Docking SimulationMolecular StructureStructure-Activity RelationshipAntineoplastic AgentsBRD4 protein, humanBromodomain Containing ProteinsCell Cycle ProteinsCoumarinsThiocarbamatesTranscription Factorsantitumor activitiesbromodomain-containing protein 4Colorectal cancercoumarin-dithiocarbamate derivatives

Identifiers

PMID33557648
PMCPMC8759731
OpenAlexW3127550094

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.