Evidence map›Paper›PMID 33557646›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2021

Synthesis and anti-rheumatoid arthritis activities of 3-(4-aminophenyl)-coumarin derivatives.

Yuhang Miao, Jie Yang, Yinling Yun, Jie Sun, Xiaojing Wang

Open access · goldAbstract read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Discovery of Coumarins fromMolecules (Basel, Switzerland) · 2024
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Glycyrrhizic acid modifiedFrontiers in chemistry · 2023
    Article
  8. Article
  9. Effects of Prunus Tomentosa Thumb Total Flavones on adjuvant arthritis in rats and regulation of autophagy.Technology and health care : official journal of the European Society for Engineering and Medicine · 2023
    Article
  10. Article
  11. Research progress of coumarins and their derivatives in the treatment of diabetes.Journal of enzyme inhibition and medicinal chemistry · 2022
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Yuhang MiaoInstitute of Materia Medica, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China.
Jie YangInstitute of Materia Medica, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China.
Yinling YunInstitute of Materia Medica, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China.
Jie SunInstitute of Materia Medica, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China.ORCID https://orcid.org/0000-0003-0552-9061
Xiaojing WangInstitute of Materia Medica, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China.
Shandong First Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rheumatoid arthritis is a chronic systemic disease characterised by an unknown aetiology of inflammatory synovitis. A large number of studies have shown that synoviocytes show tumour-like dysplasia in the pathological process of RA, and the changes in the expression of related cytokines are closely related to the pathogenesis of RA. In this thesis, a series of novel 3-(4-aminophenyl) coumarins containing different substituents were synthesised to find new coumarin anti-inflammatory drugs for the treatment of rheumatoid arthritis. The results of preliminary activity screening showed that compound

Indexed as

AnimalsAnti-Inflammatory AgentsArthritis, RheumatoidCell ProliferationCells, CulturedCoumarinsCytokinesDisease Models, AnimalDose-Response Relationship, DrugHumansMolecular StructureRatsRats, Sprague-DawleyStructure-Activity RelationshipAnti-Inflammatory AgentsCoumarinsCytokines3-(4-Aminophenyl)-coumarinanti-inflammationRA-FLSs proliferation inhibitionrheumatoid arthritis

Identifiers

PMID33557646
PMCPMC7889190
OpenAlexW3127424199

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.