Evidence map›Paper›PMID 33557518›Full record

ArticleBiochemistry2021

Allosteric Inhibition of the Epidermal Growth Factor Receptor.

Julie K L Sinclair, Wesley E Robertson, Deepto Mozumdar, Kim Quach, Alanna Schepartz

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Julie K L SinclairDepartment of Chemistry, Yale University, New Haven, Connecticut 06520, United States.
Wesley E RobertsonDepartment of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520, United States.ORCID 0000-0001-9812-8288
Deepto MozumdarDepartment of Chemistry, Yale University, New Haven, Connecticut 06520, United States.ORCID 0000-0001-7303-8681
Kim QuachDepartment of Chemistry, Yale University, New Haven, Connecticut 06520, United States.
Alanna SchepartzDepartment of Chemistry, University of California, Berkeley, California 94705, United States.ORCID 0000-0003-2127-3932
Yale University · USUniversity of California, Berkeley · US

Funding

PREDOCTORAL PROGRAM IN BIOPHYSICST32GM008283 · NIGMS · YALE UNIVERSITY · PI XIONG, YONG · 1988 to 2022
$10.5M
Predoc Training at the Interface Chemistry and BiologyT32GM067543 · NIGMS · YALE UNIVERSITY · PI CRAWFORD, JASON MICHAEL · 2003 to 2022
$7.4M
Fluorescence tools that illuminate biology and inspire translationR35GM134963 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Alanna Schepartz · 2020 to 2026
$4.7M
Surveying protein partnerships and assembly with bipartite tetracysteine displayR01GM083257 · NIGMS · YALE UNIVERSITY · PI SCHEPARTZ, ALANNA · 2008 to 2018
$3.2M
NIGMS NIH HHS R01 GM083257NIGMS NIH HHS R35 GM134963NIGMS NIH HHS T32 GM008283NIGMS NIH HHS T32 GM067543
6 · The paper itself

Abstract

We previously reported a family of hydrocarbon-stapled peptides designed to interact with the epidermal growth factor receptor (EGFR) juxtamembrane (JM) segment, blocking its ability to form a coiled coil dimer that is essential for receptor activation. These hydrocarbon-stapled peptides, most notably E1

Indexed as

Amino Acid SequenceCell Line, TumorCell MembraneErbB ReceptorsHumansMutationProtein Kinase InhibitorsStructure-Activity RelationshipEGFR protein, humanErbB ReceptorsProtein Kinase Inhibitors

Identifiers

PMID33557518
PMCPMC8815332
OpenAlexW3126884282

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.