Evidence map›Paper›PMID 33557438›Full record

ArticleInternational journal of environmental research and public health2021

XAB2 TagSNP Is Associated with the Risk of Gastric Cancer in Chinese Population: A Case-Control Study.

Yuning Xie, Yuan Yu, Hongjiao Wu, Hui Gao, Zhenbang Yang, Yi Zhang, Xuemei Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of environmental research and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yuning XieSchool of Public Health, North China University of Science and Technology, Tangshan 063210, China.
Yuan YuCollege of Life Science, North China University of Science and Technology, Tangshan 063210, China.
Hongjiao WuSchool of Public Health, North China University of Science and Technology, Tangshan 063210, China.
Hui GaoSchool of Public Health, North China University of Science and Technology, Tangshan 063210, China.
Zhenbang YangSchool of Basic Medical Sciences, North China University of Science and Technology, Tangshan 063210, China.
Yi ZhangSchool of Basic Medical Sciences, North China University of Science and Technology, Tangshan 063210, China.
Xuemei ZhangSchool of Public Health, North China University of Science and Technology, Tangshan 063210, China.
North China University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

XAB2 protein (xeroderma pigmentosum group A-binding protein 2) plays a significant role in the nucleotide excision repair pathway. Polymorphisms in the XAB2 gene may have an effect on the capability of DNA repair and further contribute to the risk of developing various cancers. In order to investigate the relationship between XAB2 genetic variants and the risk of gastric cancer, we performed a hospital-based case-control study. XAB2 tagSNPs were selected and then genotyped by iPlex Gold Genotyping Assay and Sequenom MassArray. By performing logistic regression analysis, odds ratio (OR) and 95% confidence interval (CI) were used to estimate the association of XAB2 tagSNPs with the risk of gastric cancer. Our results showed that XAB2 rs794078AA genotype was associated with a significantly lower risk of gastric cancer compared with GG genotype with OR (95% CI) of 0.33 (0.12-0.91). Stratified analysis indicated a significantly decreased risk for gastric cancer among smokers with rs794078AA genotype compared with nonsmokers with GG genotype (OR = 0.11, 95% CI = 0.01-0.91,

Indexed as

Asian PeopleCase-Control StudiesChinaGenetic Predisposition to DiseaseGenotypeHumansPolymorphism, Single NucleotideRisk FactorsRNA Splicing FactorsStomach NeoplasmsRNA Splicing FactorsXAB2 protein, humanDNA repairgastric cancerpolymorphismtranscriptional coupled repairXAB2

Identifiers

PMID33557438
PMCPMC7914850
OpenAlexW3128198342

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.