ArticleBrain sciences2021
Brain Structural Covariance Networks in Behavioral Variant of Frontotemporal Dementia.
Article in Brain sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Structural covariance analysis for neurodegenerative and neuroinflammatory brain disorders.Brain : a journal of neurology · 2025Review
- Structural covariance network patterns linked to neuropsychiatric symptoms in biologically defined Alzheimer's disease: Insights from the mild behavioral impairment checklist.Journal of Alzheimer's disease : JAD · 2025Article
- Multiplex connectomics reveal altered networks in frontotemporal dementia: A multisite study.Network neuroscience (Cambridge, Mass.) · 2025Article
- Cognitive dispersion and its functional relevance in behavioral variant frontotemporal dementia and prodromal behavioral variant frontotemporal dementia.Neuropsychology · 2024Article
- Accuracy of clinical diagnosis of behavioural variant frontotemporal dementia: a protocol for a systematic review and meta-analysis.BMJ open · 2024Article
- Clinical relevance of disrupted topological organization of anatomical connectivity in behavioral variant frontotemporal dementia.Neurobiology of aging · 2023Article
- Antemortem network analysis of spreading pathology in autopsy-confirmed frontotemporal degeneration.Brain communications · 2023Article
- Subjective cognitive decline is associated with a higher risk of objective cognitive decline: A cross-sectional and longitudinal study.Frontiers in psychiatry · 2022Article
- The Role of Graph Theory in Evaluating Brain Network Alterations in Frontotemporal Dementia.Frontiers in neurology · 2022Review
- Radiomics Model for Frontotemporal Dementia Diagnosis Using T1-Weighted MRI.Frontiers in neuroscience · 2022Article
- Exploring Signatures of Neurodegeneration in Early-Onset Older-Age Bipolar Disorder and Behavioral Variant Frontotemporal Dementia.Frontiers in neurology · 2021Article
- Investigating the Roles of Anterior Cingulate in Behavioral Variant Frontotemporal Dementia: A PET/MRI Study.Journal of Alzheimer's disease : JAD · 2021Article
- Accuracy of clinical diagnosis of behavioral variant frontotemporal dementia: A systematic review and meta-analysis.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Recent research on behavioral variant frontotemporal dementia (bvFTD) has shown that personality changes and executive dysfunctions are accompanied by a disease-specific anatomical pattern of cortical and subcortical atrophy. We investigated the structural topological network changes in patients with bvFTD in comparison to healthy controls. In particular, 25 bvFTD patients and 20 healthy controls underwent structural 3T MRI. Next, bilaterally averaged values of 34 cortical surface areas, 34 cortical thickness values, and six subcortical volumes were used to capture single-subject anatomical connectivity and investigate network organization using a graph theory approach. Relative to controls, bvFTD patients showed altered small-world properties and decreased global efficiency, suggesting a reduced ability to combine specialized information from distributed brain regions. At a local level, patients with bvFTD displayed lower values of local efficiency in the cortical thickness of the caudal and rostral middle frontal gyrus, rostral anterior cingulate, and precuneus, cuneus, and transverse temporal gyrus. A significant correlation was also found between the efficiency of caudal anterior cingulate thickness and Mini-Mental State Examination (MMSE) scores in bvFTD patients. Taken together, these findings confirm the selective disruption in structural brain networks of bvFTD patients, providing new insights on the association between cognitive decline and graph properties.
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