Evidence map›Paper›PMID 33557409›Full record

ArticleViruses2021

Characterization of Hepatitis B Virus Integrations Identified in Hepatocellular Carcinoma Genomes.

Pranav P Mathkar, Xun Chen, Arvis Sulovari, Dawei Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Pranav P MathkarDepartment of Microbiology and Molecular Genetics, University of Vermont, Burlington, VT 05405, USA.
Xun ChenDepartment of Microbiology and Molecular Genetics, University of Vermont, Burlington, VT 05405, USA.ORCID 0000-0003-0327-1888
Arvis SulovariDepartment of Microbiology and Molecular Genetics, University of Vermont, Burlington, VT 05405, USA.
Dawei LiDepartment of Microbiology and Molecular Genetics, University of Vermont, Burlington, VT 05405, USA.ORCID 0000-0002-9214-4487
University of Vermont · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality. Almost half of HCC cases are associated with hepatitis B virus (HBV) infections, which often lead to HBV sequence integrations in the human genome. Accurate identification of HBV integration sites at a single nucleotide resolution is critical for developing a better understanding of the cancer genome landscape and of the disease itself. Here, we performed further analyses and characterization of HBV integrations identified by our recently reported VIcaller platform in recurrent or known HCC genes (such as

Indexed as

Virus IntegrationCarcinogenesisCarcinoma, HepatocellularDNA, ViralGene FrequencyGenome, HumanGenome, ViralHepatitis B, ChronicHepatitis B virusHumansLiver NeoplasmsSoftwareDNA, Viralhepatitis B virus (HBV)hepatocellular carcinoma (HCC)integration allele fractionVIcallerviral integrationvirome-wide detection

Identifiers

PMID33557409
PMCPMC7915589
OpenAlexW3127640156

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.