Evidence map›Paper›PMID 33557377›Full record

ArticleBiomolecules2021

Diethylstilbestrol Modifies the Structure of Model Membranes and Is Localized Close to the First Carbons of the Fatty Acyl Chains.

Alessio Ausili, Inés Rodríguez-González, Alejandro Torrecillas, José A Teruel, Juan C Gómez-Fernández

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Alessio AusiliDepartamento de Bioquímica y Biología Molecular "A", Facultad de Veterinaria, Regional Campus of International Excellence "Campus Mare Nostrum", Universidad de Murcia, Apartado de Correos 4021, E-30080 Murcia, Spain.
Inés Rodríguez-GonzálezDepartamento de Bioquímica y Biología Molecular "A", Facultad de Veterinaria, Regional Campus of International Excellence "Campus Mare Nostrum", Universidad de Murcia, Apartado de Correos 4021, E-30080 Murcia, Spain.
Alejandro TorrecillasDepartamento de Bioquímica y Biología Molecular "A", Facultad de Veterinaria, Regional Campus of International Excellence "Campus Mare Nostrum", Universidad de Murcia, Apartado de Correos 4021, E-30080 Murcia, Spain.
José A TeruelDepartamento de Bioquímica y Biología Molecular "A", Facultad de Veterinaria, Regional Campus of International Excellence "Campus Mare Nostrum", Universidad de Murcia, Apartado de Correos 4021, E-30080 Murcia, Spain.
Juan C Gómez-FernándezDepartamento de Bioquímica y Biología Molecular "A", Facultad de Veterinaria, Regional Campus of International Excellence "Campus Mare Nostrum", Universidad de Murcia, Apartado de Correos 4021, E-30080 Murcia, Spain.ORCID 0000-0002-5331-9029
Universidad de Murcia · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The synthetic estrogen diethylstilbestrol (DES) is used to treat metastatic carcinomas and prostate cancer. We studied its interaction with membranes and its localization to understand its mechanism of action and side-effects. We used differential scanning calorimetry (DSC) showing that DES fluidized the membrane and has poor solubility in DMPC (1,2-dimyristoyl-

Indexed as

Membranes, ArtificialCalorimetry, Differential ScanningCarbonDiethylstilbestrolFatty AcidsLipid BilayersMagnetic Resonance SpectroscopyMolecular Dynamics SimulationPhase TransitionPhosphatidylcholinesPhospholipidsPhosphorus RadioisotopesProtonsSolubilityTemperatureThermodynamics1-palmitoyl-2-oleoylphosphatidylcholineCarbonDiethylstilbestrolFatty AcidsLipid BilayersMembranes, ArtificialPhosphatidylcholinesPhospholipidsPhosphorus RadioisotopesProtons1H-NOESY-MAS-NMR31P-NMRdiethylstilbestrolDSCmembranesSAXDwide-angle X-ray diffraction (WAXD)

Identifiers

PMID33557377
PMCPMC7914449
OpenAlexW3128003287

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.