Evidence map›Paper›PMID 33557298›Full record

ArticleJournal of clinical medicine2021

Leukocyte Telomere Length Is Not Reduced in Children and Adults with Cystic Fibrosis but Associates with Clinical Characteristics-A Cross-Sectional Study.

Aleksandra Glapa-Nowak, Shivaprakash Jagalur Mutt, Aleksandra Lisowska, Ewa Sapiejka, Joanna Goździk-Spychalska, Mirosława Wieczorek-Filipiak, Sławomira Drzymała-Czyż, Jan Krzysztof Nowak, Olaf Thalmann, Karl-Heinz Herzig and 1 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. The ageing of people living with cystic fibrosis: what to expect now?European respiratory review : an official journal of the European Respiratory Society · 2024
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Aleksandra Glapa-NowakDepartment of Paediatric Gastroenterology and Metabolic Diseases, Poznań University of Medical Sciences, 60-572 Poznań, Poland.ORCID 0000-0002-3017-0524
Shivaprakash Jagalur MuttResearch Unit of Biomedicine, University of Oulu, 90220 Oulu, Finland.ORCID 0000-0001-8285-551X
Aleksandra LisowskaDepartment of Paediatric Gastroenterology and Metabolic Diseases, Poznań University of Medical Sciences, 60-572 Poznań, Poland.
Ewa SapiejkaThe Specialist Centre for Medical Care of Mother and Child, 80-308 Gdańsk, Poland.
Joanna Goździk-SpychalskaDepartment of Pulmonology, Allergology and Respiratory Oncology, Poznan University of Medical Sciences, 60-569 Poznań, Poland.ORCID 0000-0002-4518-7070
Mirosława Wieczorek-FilipiakDepartment of Paediatric Gastroenterology and Metabolic Diseases, Poznań University of Medical Sciences, 60-572 Poznań, Poland.
Sławomira Drzymała-CzyżDepartment of Paediatric Gastroenterology and Metabolic Diseases, Poznań University of Medical Sciences, 60-572 Poznań, Poland.
Jan Krzysztof NowakDepartment of Paediatric Gastroenterology and Metabolic Diseases, Poznań University of Medical Sciences, 60-572 Poznań, Poland.
Olaf ThalmannDepartment of Paediatric Gastroenterology and Metabolic Diseases, Poznań University of Medical Sciences, 60-572 Poznań, Poland.
Karl-Heinz HerzigDepartment of Paediatric Gastroenterology and Metabolic Diseases, Poznań University of Medical Sciences, 60-572 Poznań, Poland.ORCID 0000-0003-4460-2604
Jarosław WalkowiakDepartment of Paediatric Gastroenterology and Metabolic Diseases, Poznań University of Medical Sciences, 60-572 Poznań, Poland.ORCID 0000-0001-5813-5707
Poznan University of Medical Sciences · PLOulu University Hospital · FI

Funding

Narodowe Centrum Nauki 2017/25/N/NZ5/02126
6 · The paper itself

Abstract

We hypothezied that telomere length is considerably altered in cystic fibrosis (CF) patients compared to healthy subjects (HS), and that leukocyte telomere length variation reflects the severity of CF. Relative telomere length (RTL) was assessed by qPCR in 70 children aged 5-10 (34 CF; 36 HS) and 114 adults aged 18-45 (53 CF; 61 HS). Telomere length was similar in CF and HS (median (interquartile range): 0.799 (0.686-0.950) vs. 0.831 (0.707-0.986);

Indexed as

CFTRdried blood spotsinhaled corticosteroidspancreatic insufficiencyPseudomonas aeruginosa

Identifiers

PMID33557298
PMCPMC7915028
OpenAlexW3127772842

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.