Evidence map›Paper›PMID 33557217›Full record

ArticleInternational journal of molecular sciences2021

Plasma miR-9-3p and miR-136-3p as Potential Novel Diagnostic Biomarkers for Experimental and Human Mild Traumatic Brain Injury.

Shalini Das Gupta, Robert Ciszek, Mette Heiskanen, Niina Lapinlampi, Janne Kukkonen, Ville Leinonen, Noora Puhakka, Asla Pitkänen

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Article
  7. Unveiling the predictive power of biomarkers in traumatic brain injury: A narrative review focused on clinical outcomes.Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia · 2025
    Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Oral SpirocheteInternational journal of molecular sciences · 2023
    Article
  13. Article
  14. Article
  15. Review
  16. Profiling Secreted miRNA Biomarkers of Chemical-Induced Neurodegeneration in Human iPSC-Derived Neurons.Toxicological sciences : an official journal of the Society of Toxicology · 2022
    Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Shalini Das GuptaA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, P.O. Box 1627, 70211 Kuopio, Finland.
Robert CiszekA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, P.O. Box 1627, 70211 Kuopio, Finland.
Mette HeiskanenA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, P.O. Box 1627, 70211 Kuopio, Finland.ORCID 0000-0003-1624-5240
Niina LapinlampiA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, P.O. Box 1627, 70211 Kuopio, Finland.ORCID 0000-0003-3210-6312
Janne KukkonenDepartment of Neurosurgery, Kuopio University Hospital, 70029 Kuopio, Finland.
Ville LeinonenDepartment of Neurosurgery, Kuopio University Hospital, 70029 Kuopio, Finland.
Noora PuhakkaA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, P.O. Box 1627, 70211 Kuopio, Finland.
Asla PitkänenA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, P.O. Box 1627, 70211 Kuopio, Finland.
University of Eastern Finland · FI

Funding

ELECTROPHYSIOLOGICAL PROPERTIES OF AMYGDALAF32NS010006 · NINDS · LAVAL UNIVERSITY · PI LANG, ERIC J · 1995 to 1997
–
Academy of Finland 272249, 273909, and 2285733-9NINDS NIH HHS Centres without Walls [grant number U54 NS100064]Seventh Framework Programme (FP7/2007-2013) under grant agreement n°602102 (EPITARGET)
6 · The paper itself

Abstract

Noninvasive, affordable circulating biomarkers for difficult-to-diagnose mild traumatic brain injury (mTBI) are an unmet medical need. Although blood microRNA (miRNA) levels are reportedly altered after traumatic brain injury (TBI), their diagnostic potential for mTBI remains inconclusive. We hypothesized that acutely altered plasma miRNAs could serve as diagnostic biomarkers both in the lateral fluid percussion injury (FPI) model and clinical mTBI. We performed plasma small RNA-sequencing from adult male Sprague-Dawley rats (

Indexed as

BiomarkersAgedAnimalsBrain Injuries, TraumaticCase-Control StudiesComputational BiologyDisease Models, AnimalFemaleGene Expression ProfilingHigh-Throughput Nucleotide SequencingHumansMachine LearningMaleMicroRNAsMiddle AgedPrognosisBiomarkersMicroRNAsMIRN136 microRNA, humanMIRN92 microRNA, humanbiomarkermicroRNAmild TBImiR-136-3pmiR-9-3pplasmasevere TBI

Identifiers

PMID33557217
PMCPMC7913923
OpenAlexW3128181655

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.