Evidence map›Paper›PMID 33557199›Full record

ArticleCells2021

Characterization of Early-Onset Finger Osteoarthritis-Like Condition Using Patient-Derived Induced Pluripotent Stem Cells.

Yeri Alice Rim, Yoojun Nam, Narae Park, Kijun Lee, Hyerin Jung, Seung Min Jung, Jennifer Lee, Ji Hyeon Ju

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yeri Alice RimCatholic iPSC Research Center, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.ORCID 0000-0001-9541-3075
Yoojun NamCatholic iPSC Research Center, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
Narae ParkCatholic iPSC Research Center, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
Kijun LeeCatholic iPSC Research Center, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
Hyerin JungCatholic iPSC Research Center, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
Seung Min JungCatholic iPSC Research Center, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
Jennifer LeeDepartment of Internal Medicine, Division of Rheumatology, Institute of Medical Science, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul 06591, Korea.
Ji Hyeon JuCatholic iPSC Research Center, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.ORCID 0000-0002-1381-5466
Catholic University of Korea · KRThe Catholic University of Korea Seoul St. Mary's Hospital · KR

Funding

Ministry for Health, Welfare and Family Affairs, RMinistry for Health, Welfare and Family Affairs, RKorean Ministry for Health, Welfare, and Family Affairs HI16C2177Ministry for Health, Welfare and Family Affairs, RMinistry for Health, Welfare and Family Affairs, RKorean Ministry for Health, Welfare, and Family Affairs HI18C1178National Research Foundation of Korea 2019R1I1A1A01060753National Research Foundation of Korea 2019R1I1A1A01062060
6 · The paper itself

Abstract

Early osteoarthritis (OA)-like symptoms are difficult to study owing to the lack of disease samples and animal models. In this study, we generated induced pluripotent stem cell (iPSC) lines from a patient with a radiographic early-onset finger osteoarthritis (efOA)-like condition in the distal interphalangeal joint and her healthy sibling. We differentiated those cells with similar genetic backgrounds into chondrogenic pellets (CPs) to confirm efOA. CPs generated from efOA-hiPSCs (efOA-CPs) showed lower levels of

Indexed as

Age of OnsetCell DifferentiationChondrogenesisCore Binding Factor Alpha 1 SubunitCytokinesFibroblastsGene Expression RegulationHumansInduced Pluripotent Stem CellsInflammation MediatorsMatrix MetalloproteinasesOsteoarthritisVascular Endothelial Growth Factor ACore Binding Factor Alpha 1 SubunitCytokinesInflammation MediatorsMatrix MetalloproteinasesVascular Endothelial Growth Factor Achondrogenesishuman induced pluripotent stem cellIL-6MMP1MMP10

Identifiers

PMID33557199
PMCPMC7913990
OpenAlexW3127383817

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.