Evidence map›Paper›PMID 33557143›Full record

ArticleBiomedicines2021

Bacterial Genotoxin-Coated Nanoparticles for Radiotherapy Sensitization in Prostate Cancer.

Yu-An Chen, Yi-Ru Lai, Hui-Yu Wu, Yen-Ju Lo, Yu-Fang Chang, Chiu-Lien Hung, Chun-Jung Lin, U-Ging Lo, Ho Lin, Jer-Tsong Hsieh and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Review
  3. Anti-cancer efficiency ofCytotechnology · 2025
    Article
  4. Review
  5. Prostate Cancer Stem Cells: Biology and Treatment Implications.International journal of molecular sciences · 2023
    Review
  6. Review
  7. Review
  8. Extracellular Vesicles fromInternational journal of molecular sciences · 2022
    Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 2 countries.

Yu-An ChenDepartment of Microbiology and Immunology, Graduate Institute of Biomedical Sciences, Chang Gung University, Taoyuan 33302, Taiwan.
Yi-Ru LaiDepartment of Microbiology and Immunology, Graduate Institute of Biomedical Sciences, Chang Gung University, Taoyuan 33302, Taiwan.
Hui-Yu WuDepartment of Microbiology and Immunology, Graduate Institute of Biomedical Sciences, Chang Gung University, Taoyuan 33302, Taiwan.
Yen-Ju LoDepartment of Microbiology and Immunology, Graduate Institute of Biomedical Sciences, Chang Gung University, Taoyuan 33302, Taiwan.
Yu-Fang ChangDepartment of Microbiology and Immunology, Graduate Institute of Biomedical Sciences, Chang Gung University, Taoyuan 33302, Taiwan.
Chiu-Lien HungTargeted Drug and Delivery Technology Division, Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, Hsinchu 30011, Taiwan.
Chun-Jung LinDepartment of Urology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
U-Ging LoDepartment of Urology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Ho LinDepartment of Life Sciences, National Chung Hsing University, Taichung 40227, Taiwan.ORCID 0000-0001-7849-9137
Jer-Tsong HsiehDepartment of Urology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-1919-6010
Cheng-Hsun ChiuDepartment of Microbiology and Immunology, Graduate Institute of Biomedical Sciences, Chang Gung University, Taoyuan 33302, Taiwan.
Yu-Hsin LinDepartment of Medical Research, School of Medicine, China Medical University and Hospital, Taichung 40447, Taiwan.
Chih-Ho LaiDepartment of Microbiology and Immunology, Graduate Institute of Biomedical Sciences, Chang Gung University, Taoyuan 33302, Taiwan.ORCID 0000-0001-7145-784X
Chang Gung University · TWNational Chung Hsing University · TWThe University of Texas Southwestern Medical Center · USAsia University · TWChina Medical University · TWIndustrial Technology Research Institute · TWNational Yang Ming Chiao Tung University · TW

Funding

Chang Gung Memorial Hospital, Linkou CMRPD1I0061-3, CMRPD1J0021-3, CMRPD1K0361, and BMRPE90Ministry of Science and Technology, Taiwan 108-2911-I-005-509, 109-2911-I-005-503, 109-2320-B-182-025-MY3, and 109-2320-B-182-029-MY3
6 · The paper itself

Abstract

Prostate cancer (PCa) is one of the most commonly diagnosed cancers in men and usually becomes refractory because of recurrence and metastasis. CD44, a transmembrane glycoprotein, serves as a receptor for hyaluronic acid (HA). It has been found to be abundantly expressed in cancer stem cells (CSCs) that often exhibit a radioresistant phenotype. Cytolethal distending toxin (CDT), produced by

Indexed as

genotoxinnanoparticlesprostate cancerradioresistance

Identifiers

PMID33557143
PMCPMC7913852
OpenAlexW3126251944

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.