ReviewJournal of clinical medicine2021
Oral Complications of ICU Patients with COVID-19: Case-Series and Review of Two Hundred Ten Cases.
Review in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 6 syntheses or guidelines pooled it, 107 citations in OpenAlex.
- Prevalence of oral manifestations in COVID-19: A systematic review.Reviews in medical virology · 2022Pooled it
- Oral mucosa lesions in confirmed and non-vaccinated cases for COVID-19: A systematic review.Journal of stomatology, oral and maxillofacial surgery · 2022Pooled it
- Oral manifestations of multisystemic inflammatory syndrome in children (MIS-C) and Kawasaki disease associated to COVID-19: A systematic review.Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry · 2022Pooled it
- Oral Health Implications of SARS-CoV-2/COVID-19: A Systematic Review.Oral health & preventive dentistry · 2022Pooled it
- Oral Manifestations of COVID-19 in Hospitalized Patients: A Systematic Review.International journal of environmental research and public health · 2021Pooled it
- Oral Manifestations of COVID-19: Updated Systematic Review With Meta-Analysis.Frontiers in medicine · 2021Pooled it
- The effect of artificial saliva on the control of dry mouth: a semi-experimental study on COVID-19 patients under Non-invasive mechanical ventilation.BMC oral health · 2024Trial
- Efficacy of artificial saliva in preventing oral changes in patients admitted to the ICU: a controlled clinical trial.Clinical oral investigations · 2026Article
- Oral Manifestations, Dental Interventions, and Clinical Outcomes in Hospitalized COVID-19 Patients: A Two-Year Cohort Study in São Paulo, Brazil.Dentistry journal · 2025Article
- Article
- Oral condition of patients hospitalized for Covid-19 and its impact on quality of life.Brazilian oral research · 2025Article
- Awareness of undergraduate dental students, interns, and freshly graduated dentists about oral manifestation associated with COVID-19.BMC oral health · 2023Article
- Estimating the prevalence of oral manifestations in COVID-19 patients: a systematic review.Osong public health and research perspectives · 2023Article
- Critical roles of cytokine storm and bacterial infection in patients with COVID-19: therapeutic potential of mesenchymal stem cells.Inflammopharmacology · 2023Review
- The Oral Lesion in the COVID-19 Patient: Is It True Oral Manifestation or Not?Infection and drug resistance · 2023Review
- A reflection on COVID-19 and oral mucosal lesion: a systematic review.Frontiers in oral health · 2023Review
- Article
- Oral Lesions Associated with COVID-19 and the Participation of the Buccal Cavity as a Key Player for Establishment of Immunity against SARS-CoV-2.International journal of environmental research and public health · 2022Review
- Differences in Oral Lesions Associated with Tobacco Smoking, E-Cigarette Use and COVID-19 Infection among Adolescents and Young People in Nigeria.International journal of environmental research and public health · 2022Article
- Complications of invasive mechanical ventilation in critically Ill Covid-19 patients - A narrative review.Annals of medicine and surgery (2012) · 2022Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundThe critically ill patients suffering from coronavirus disease (COVID-19) and admitted to the intensive care units (ICUs) are susceptible to a wide array of complications that can be life-threatening or impose them to long-term complications. The COVID-19 oral mucocutaneous complications require multidisciplinary management and research for their pathophysiological course and epidemiological significance; therefore, the objective of this study was to evaluate the prevalence and characteristics of the critically ill COVID-19 patients with oral complications.
methodsWe described the clinical and microbiological characteristics of the critically ill COVID-19 patients in our ICU department (Banska Bystrica, Slovakia). In addition, we reviewed the current body of evidence in Ovid MEDLINE
resultsThree out of nine critically ill patients (33.3%) in our ICU department presented with oral complications including haemorrhagic ulcers and necrotic ulcers affecting the lips and tongue. The microbiological assessment revealed the presence of opportunistic pathogens, confirming the possibility of co-infection. On reviewing the current literature, two hundred ten critically ill patients were reported to have oral complications due to their stay in the ICU setting. Perioral pressure ulcers were the most common complication, followed by oral candidiasis, herpetic and haemorrhagic ulcers, and acute onset macroglossia. The prolonged prone positioning and mechanical ventilation devices were the primary risk factors for those oral complications, in addition to the immunosuppressive drugs.
conclusionsThe multidisciplinary approach is strongly advocated for monitoring and management of COVID-19 patients, thus implying that dermatology and oral healthcare specialists and nurses should be integrated within the ICU teams.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.