ArticleDevelopmental cognitive neuroscience2021
Decomposing complex links between the childhood environment and brain structure in school-aged youth.
Article in Developmental cognitive neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 39 citations in OpenAlex.
- From school climate to brain development: What the ABCD study reveals about the educational context of adolescence.Developmental cognitive neuroscience · 2026Review
- Adversity and adolescent brain development: differential associations with grey and white matter across two longitudinal cohorts.bioRxiv : the preprint server for biology · 2026Article
- The effect of the "exposome" on developmental brain health and cognitive outcomes.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Identifying subtypes based on environmental and neurobiological risk and resilience factors of postpartum maternal mental health.Translational psychiatry · 2025Article
- Leveraging multivariate approaches to advance the science of early-life adversity.Child abuse & neglect · 2025Review
- Brain-clinical biotyping in patients with idiopathic REM sleep behavior disorder.NPJ Parkinson's disease · 2025Article
- Mapping the neurodevelopmental predictors of psychopathology.Molecular psychiatry · 2025Article
- Perception of social experiences and cortical thickness change together throughout early adolescence: Findings from the ABCD cohort.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- The impact of psychosocial adversity on brain and behaviour: an overview of existing knowledge and directions for future research.Molecular psychiatry · 2024Review
- From mother to child: How intergenerational transfer is reflected in similarity of corticolimbic brain structure and mental health.Developmental cognitive neuroscience · 2023Article
- Neurobiological Clusters Are Associated With Trajectories of Overall Psychopathology in Youth.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2023Article
- Characterizing the dimensional structure of early-life adversity in the Adolescent Brain Cognitive Development (ABCD) Study.Developmental cognitive neuroscience · 2023Article
- Parsing brain-behavior heterogeneity in very preterm born children using integrated similarity networks.Translational psychiatry · 2023Article
- Associations between neighborhood socioeconomic status, parental education, and executive system activation in youth.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Neurodevelopmental mechanisms linking early experiences and mental health: Translating science to promote well-being among youth.The American psychologist · 2022Article
- Leveraging the science of stress to promote resilience and optimize mental health interventions during adolescence.Nature communications · 2022Article
- A practical guide for researchers and reviewers using the ABCD Study and other large longitudinal datasets.Developmental cognitive neuroscience · 2022Article
- Stress and adolescence: vulnerability and opportunity during a sensitive window of development.Current opinion in psychology · 2022Review
- Factors of Family Violence in the Southern Province of Rwanda.Rwanda journal of medicine and health sciences · 2022Article
- Neural impact of neighborhood socioeconomic disadvantage in traumatically injured adults.Neurobiology of stress · 2021Article
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
Childhood experiences play a profound role in conferring risk and resilience for brain and behavioral development. However, how different facets of the environment shape neurodevelopment remains largely unknown. Here we sought to decompose heterogeneous relationships between environmental factors and brain structure in 989 school-aged children from the Adolescent Brain Cognitive Development Study. We applied a cross-modal integration and clustering approach called 'Similarity Network Fusion', which combined two brain morphometrics (i.e., cortical thickness and myelin-surrogate markers), and key environmental factors (i.e., trauma exposure, neighborhood safety, school environment, and family environment) to identify homogeneous subtypes. Depending on the subtyping resolution, results identified two or five subgroups, each characterized by distinct brain structure-environment profiles. Notably, more supportive caregiving and school environments were associated with greater myelination, whereas less supportive caregiving, higher family conflict and psychopathology, and higher perceived neighborhood safety were observed with greater cortical thickness. These subtypes were highly reproducible and predicted externalizing symptoms and overall mental health problems. Our findings support the theory that distinct environmental exposures are differentially associated with alterations in structural neurodevelopment. Delineating more precise associations between risk factors, protective factors, and brain development may inform approaches to enhance risk identification and optimize interventions targeting specific experiences.
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