ArticleEuropean journal of obstetrics, gynecology, and reproductive biology2021
COVID-19 as an independent risk factor for subclinical placental dysfunction.
Article in European journal of obstetrics, gynecology, and reproductive biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 3 of them syntheses that pooled it.
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The trial behind it
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Who cites it
39 citing papers in PubMed, 3 syntheses or guidelines pooled it, 73 citations in OpenAlex.
- Effect of COVID-19 on Pregnancy and Neonate's Vital Parameters: A Systematic Review.Journal of pregnancy · 2023Pooled it
- SARS-CoV-2 infection during pregnancy and risk of preeclampsia: a systematic review and meta-analysis.American journal of obstetrics and gynecology · 2022Pooled it
- Meta-analysis on COVID-19-pregnancy-related placental pathologies shows no specific pattern.Placenta · 2022Pooled it
- The MRI two-perfusion IVIM model improves understanding of SARS-CoV-2 virus impact on placental tissue.Magma (New York, N.Y.) · 2026Article
- Article
- Impact of SARS-CoV-2 on intrapartum cardiotocography: a retrospective cohort study.BMC pregnancy and childbirth · 2025Article
- Maternal Obesity Modifies the Impact of Active SARS-CoV-2 Infection on Placental Pathology.Viruses · 2025Article
- The effect of COVID-19 on placental functioning in South African pregnancies: investigation of kisspeptin expression and vascular and inflammatory alterations.Histochemistry and cell biology · 2025Article
- Preeclamptic Placental CD19+ B Cells Are Causal to Hypertension During Pregnancy.Hypertension (Dallas, Tex. : 1979) · 2025Article
- SARS-CoV-2 Infection during Delivery Causes Histopathological Changes in the Placenta.Diseases (Basel, Switzerland) · 2024Article
- Winter, spring, summer or fall: temporal patterns in placenta-mediated pregnancy complications-an exploratory analysis.Archives of gynecology and obstetrics · 2024Article
- Impact of COVID-19 disease on placental histopathology. PLAXAVID study.Histology and histopathology · 2024Observational
- Effects of permanent placental injury due to severe acute respiratory syndrome coronavirus 2 infection during pregnancy on the feto-placental circulation: a cross-sectional study.Revista da Associacao Medica Brasileira (1992) · 2024Article
- Maternal COVID-19 exposure and placental characteristics.PloS one · 2024Article
- Impact of COVID-19 on Fetal Outcomes in Pregnant Women: A Systematic Review and Meta-Analysis.Journal of personalized medicine · 2023Review
- Activation of the Interferon Pathway in Trophoblast Cells Productively Infected with SARS-CoV-2.Stem cells and development · 2023Article
- Impact of SARS-CoV-2 Infection on Unvaccinated Pregnant Women: Non-Reassuring Fetal Heart Rate Tracing Because of Placentitis.Viruses · 2023Article
- Foetal Intrapartum Compromise at Term: Could COVID-19 Infection Be Involved? A Case Report.Medicina (Kaunas, Lithuania) · 2023Article
- Pregnancy Outcomes in SARS-CoV-2-Positive Patients: A 20-Month Retrospective Analysis of Delivery Cases.Medicina (Kaunas, Lithuania) · 2023Article
- COVID-19 and hepatic injury: cellular and molecular mechanisms in diverse liver cells.World journal of gastroenterology · 2023Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe pandemic of the severe acute respiratory distress syndrome-associated Coronavirus-2 (SARS-CoV-2) has affected millions around the world. In pregnancy the dangers to the mother and fetus are still being explored. SARS-CoV2 can potentially compromise maternal and neonatal outcomes and this may be dependent on the pregnancy stage during which the infection occurs.
objectiveThe present study was done to find the histopathological alterations in the placenta of SARS-CoV-2 positive pregnancies with either no symptoms or mild coronavirus disease (COVID)-19 related symptoms and its association with neonatal outcomes. STUDY
designThis was a prospective analytical study. Twenty seven asymptomatic or mildly symptomatic SARS-CoV-2 positive pregnant women with a singleton pregnancy delivered between 1
resultsThe baseline characteristics were comparable between the cases and controls. The following features of maternal vascular malperfusion (MVM) were significantly higher in the placentae of COVID-19 positive pregnancies: retroplacental hematomas (RPH), accelerated villous maturation (AVM), distal villous hyperplasia (DVH), atherosis, fibrinoid necrosis, mural hypertrophy of membrane arterioles (MHMA), vessel ectasia and persistence of intramural endovascular trophoblast (PIEVT). Fetal vascular malperfusion (FVM) significantly associated with the positive pregnancies were chorioangiosis, thrombosis of the fetal chorionic plate (TFCP), intramural fibrin deposition (IMFD) and vascular ectasia. Additionally, perivillous fibrin deposition was also significantly higher in the placentae of cases. The percentage of spontaneously delivered women was comparable in the two groups. The sex and weight of the newborn and the number of live births were comparable between the two groups.
conclusionsAsymptomatic or mildly symptomatic SARS-CoV-2 positive pregnant women, with otherwise uncomplicated pregnancies, show evidence of placental injury at a microscopic level. Similar findings have been demonstrated in other studies too. This placental injury apparently does not lead to poor pregnancy outcomes. The extent of this injury in symptomatic cases of COVID-19 pregnancies and its consequences on the outcomes need to be analysed.
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