Evidence map›Paper›PMID 33556714›Full record

ArticleInternational journal of hygiene and environmental health2021

Household mold, pesticide use, and childhood asthma: A nationwide study in the U.S.

Siyuan Xiao, Amanda L Ngo, Pauline Mendola, Michael N Bates, Anna L Barcellos, Assiamira Ferrara, Yeyi Zhu

Open access · greenAbstract read
In one paragraph

Article in International journal of hygiene and environmental health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. The Impact of the Indoor Environment on Childhood Asthma.Current allergy and asthma reports · 2025
    Review
  5. Childhood asthma exacerbations on the Navajo Nation.The journal of allergy and clinical immunology. In practice · 2024
    Article
  6. Article
  7. Article
  8. The Role of Climate Change in Asthma.Advances in experimental medicine and biology · 2023
    Article
  9. Article
  10. Article
  11. Climate change and allergic diseases: A scoping review.The journal of climate change and health
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Siyuan XiaoSchool of Public Health, University of California, Berkeley, United States.
Amanda L NgoKaiser Permanente Northern California Division of Research, Oakland, CA, United States.
Pauline MendolaDivision of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, United States.
Michael N BatesSchool of Public Health, University of California, Berkeley, United States.
Anna L BarcellosSchool of Public Health, University of California, Berkeley, United States.
Assiamira FerraraKaiser Permanente Northern California Division of Research, Oakland, CA, United States.
Yeyi ZhuKaiser Permanente Northern California Division of Research, Oakland, CA, United States; Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, United States. Electronic address: yeyi.zhu@kp.org.
Kaiser Permanente · USUniversity of California, Berkeley · USEunice Kennedy Shriver National Institute of Child Health and Human Development · US

Funding

Early Life Exposure to Endocrine Disrupting Chemicals and Child Growth, Adiposity, and NeurodevelopmentUH3OD023289 · OD · KAISER FOUNDATION RESEARCH INSTITUTE · PI ASSIAMIRA FERRARA, Monique Marie Hedderson · 2018 to 2026
$25.1M
Fetal Programming of Growth and Obesity: A Metabolomics ApproachK01DK120807 · NIDDK · KAISER FOUNDATION RESEARCH INSTITUTE · PI ZHU, YEYI · 2019 to 2022
$699k
NIDDK NIH HHS K01 DK120807NIH HHS UH3 OD023289
6 · The paper itself

Abstract

objectivesTo investigate the associations of household mold and pesticide use with risk of childhood asthma and examine the potential effect modification by child's sex at a national level in the U.S.

methodsNationally representative data were drawn from the cross-sectional 2017 and 2018 National Surveys of Children's Health. Household mold and pesticide exposures during the past 12 months and physician-diagnosed childhood asthma were assessed by standard questionnaires administered to primary caregivers. Multivariable logistic regression models were used to calculate adjusted odds ratios (aOR) for current asthma, adjusting for child, caregiver, and household covariates. We also examined potential effect modification by child's sex. Sampling weights accounted for the complex survey design.

resultsAmong 41,423 U.S. children in 2017-2018, the weighted prevalence of current asthma was 10.8% in household mold-exposed children, compared with 7.2% in non-exposed children (P < 0.001). After adjusting for covariates including child's obesity, children with household mold exposure compared to those with no household mold exposure had a 1.41-fold (95% CI: 1.07, 1.87) higher odds of current asthma. Associations between household mold and current asthma were pronounced among boys (aOR 1.57; 95% CI: 1.03-2.38) but not girls (aOR 1.28; 0.90-1.83; P for interaction <0.001). No significant associations were observed between household pesticide use and current asthma, after adjusting for covariates.

conclusionsOur findings suggest that household mold is associated with current asthma among children, independent of other major risk factors including child's obesity status. Our findings may inform strategies targeting mitigation of household mold as an important indoor environment factor to address childhood asthma.

Indexed as

AsthmaPesticidesChildCross-Sectional StudiesFungiHumansMaleRisk FactorsPesticidesAsthmaIndoor environmentNational surveyPublic health

Identifiers

PMID33556714
PMCPMC7965337
OpenAlexW3126330621

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.