Evidence map›Paper›PMID 33556295›Full record

ArticleAmerican journal of respiratory cell and molecular biology2021

Platelets Independently Recruit into Asthmatic Lungs and Models of Allergic Inflammation via CCR3.

Sajeel A Shah, Varsha Kanabar, Yanira Riffo-Vasquez, Zainab Mohamed, Simon J Cleary, Christopher Corrigan, Alan L James, John G Elliot, Janis K Shute, Clive P Page and 1 more

Open access · hybridAbstract read
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Increased platelet counts are associated with female sex and asthma severity.The journal of allergy and clinical immunology. Global · 2025
    Article
  7. Platelets engage mast cells in a bilateral IL-33-driven feed-forward loop.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  8. Article
  9. Review
  10. Review
  11. Exploring bias in platelet P2YBritish journal of pharmacology · 2024
    Review
  12. Stimulation of platelet P2YBritish journal of pharmacology · 2024
    Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Platelets: a potential role in chronic respiratory diseases?European respiratory review : an official journal of the European Respiratory Society · 2021
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Sajeel A ShahSackler Institute of Pulmonary Pharmacology, Institute of Pharmaceutical Science, School of Cancer and Pharmaceutical Sciences, and.
Varsha KanabarSackler Institute of Pulmonary Pharmacology, Institute of Pharmaceutical Science, School of Cancer and Pharmaceutical Sciences, and.
Yanira Riffo-VasquezSackler Institute of Pulmonary Pharmacology, Institute of Pharmaceutical Science, School of Cancer and Pharmaceutical Sciences, and.ORCID 0000-0002-2137-9430
Zainab MohamedSackler Institute of Pulmonary Pharmacology, Institute of Pharmaceutical Science, School of Cancer and Pharmaceutical Sciences, and.
Simon J ClearySackler Institute of Pulmonary Pharmacology, Institute of Pharmaceutical Science, School of Cancer and Pharmaceutical Sciences, and.ORCID 0000-0001-5573-6363
Christopher CorriganMRC-Asthma UK Centre for Allergic Mechanisms in Asthma, Guy's Hospital-King's College London, London, United Kingdom.ORCID 0000-0002-0706-6534
Alan L JamesDepartment of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia; and.ORCID 0000-0002-6018-0547
John G ElliotDepartment of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia; and.ORCID 0000-0002-4899-2948
Janis K ShuteInstitute of Biomedical and Biomolecular Sciences, University of Portsmouth, Portsmouth, United Kingdom.ORCID 0000-0002-6586-7583
Clive P PageSackler Institute of Pulmonary Pharmacology, Institute of Pharmaceutical Science, School of Cancer and Pharmaceutical Sciences, and.ORCID 0000-0002-9358-3799
Simon C PitchfordSackler Institute of Pulmonary Pharmacology, Institute of Pharmaceutical Science, School of Cancer and Pharmaceutical Sciences, and.ORCID 0000-0003-3961-0407
Sir Charles Gairdner Hospital · AUGuy's Hospital · GBUniversity of Portsmouth · GB

Funding

Medical Research Council MR/K50130X/1
6 · The paper itself

Abstract

Platelet activation and pulmonary recruitment occur in patients with asthma and in animal models of allergic asthma, in which leukocyte infiltration, airway remodeling, and hyperresponsiveness are suppressed by experimental platelet depletion. These observations suggest the importance of platelets to various characteristics of allergic disease, but the mechanisms of platelet migration and location are not understood. The aim of this study was to assess the mechanism of platelet recruitment to extravascular compartments of lungs from patients with asthma and after allergen challenge in mice sensitized to house dust mite (HDM) extract (contains the DerP1 [

Indexed as

AdolescentAdultAgedAllergensAnimalsAntigens, DermatophagoidesArthropod ProteinsAsthmaBlood PlateletsBronchial HyperreactivityChildCysteine EndopeptidasesDisease Models, AnimalFemaleGene ExpressionHumansAllergensAntigens, DermatophagoidesArthropod ProteinsCcr3 protein, mouseCcr4 protein, mouseCXCR4 protein, mouseCysteine EndopeptidasesDermatophagoides pteronyssinus antigen p 1Receptors, CCR3Receptors, CCR4Receptors, CXCR4allergenasthmaCCR3migrationplatelets

Identifiers

PMID33556295
PMCPMC8086046
OpenAlexW3127252072

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.