Evidence map›Paper›PMID 33556157›Full record

ArticleOpen forum infectious diseases2021

Real-World Inpatient Use of Medications Repurposed for Coronavirus Disease 2019 in United States Hospitals, March-May 2020.

Sameer S Kadri, Cumhur Y Demirkale, Junfeng Sun, Lindsay M Busch, Jeffrey R Strich, Ning Rosenthal, Sarah Warner

Open access · goldAbstract readComment
In one paragraph

Article in Open forum infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Sameer S KadriCritical Care Medicine Department, NIH Clinical Center, Bethesda, Maryland, USA.ORCID 0000-0002-4420-9004
Cumhur Y DemirkaleCritical Care Medicine Department, NIH Clinical Center, Bethesda, Maryland, USA.
Junfeng SunCritical Care Medicine Department, NIH Clinical Center, Bethesda, Maryland, USA.
Lindsay M BuschDivision of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia, USA.
Jeffrey R StrichCritical Care Medicine Department, NIH Clinical Center, Bethesda, Maryland, USA.
Ning RosenthalPremier Inc., Charlotte, North Carolina, USA.
Sarah WarnerCritical Care Medicine Department, NIH Clinical Center, Bethesda, Maryland, USA.
National Institutes of Health Clinical Center · USEmory University · USPremier Research Group · US

Funding

Big Data - Epidemiology of Critical Illness and SepsisZIACL090045 · CLC · CLINICAL CENTER · PI KADRI, SAMEER · 2017 to 2025
$0k
6 · The paper itself

Abstract

We report off-label use patterns for medications repurposed for coronavirus disease 2019 (COVID-19) at 318 US hospitals. Inpatient hydroxychloroquine use declined by 80%, whereas corticosteroids and tocilizumab were initiated 2 days earlier in May versus March 2020. Two thirds of ventilated COVID-19 patients were already receiving corticosteroids during March-May 2020, resembling pre-COVID use in mechanically ventilated influenza patients.

Indexed as

COVID-19medicationsrepurposedSARS-CoV-2trends

Identifiers

PMID33556157
PMCPMC7798707
OpenAlexW3111161398

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.