ArticlePLoS computational biology2021
Ephaptic coupling in white matter fibre bundles modulates axonal transmission delays.
Article in PLoS computational biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Dystonia Secondary to Intramedullary Lesion of Spinal Cord: A Case Report.Annals of Indian Academy of Neurology · 2026Article
- A historical review of ephaptic field research: from early foundations through contemporary renaissance.Frontiers in human neuroscience · 2026Review
- Reproducible Human Neural Circuits Printed with Single-Cell Precision Reveal the Functional Roles of Ephaptic Coupling.ACS nano · 2025Article
- A focus on the normal-appearing white and gray matter within the multiple sclerosis brain: a link to smoldering progression.Acta neuropathologica · 2025Review
- Cortical white matter: no longer a silent partner.Frontiers in neuroanatomy · 2025Review
- Oscillatory Transcranial Electrical Stimulation and the Amplitude-Modulated Frequency Dictate the Quantitative Features of Phosphenes.The European journal of neuroscience · 2025Article
- Thermal effects and ephaptic entrainment in Hodgkin-Huxley model.Scientific reports · 2024Article
- Review
- Impact of Extracellular Current Flow on Action Potential Propagation in Myelinated Axons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Cognition is an emergent property.Current opinion in behavioral sciences · 2024Article
- Can ephapticity contribute to brain complexity?PloS one · 2024Article
- Evolutionary origins of synchronization for integrating information in neurons.Frontiers in cellular neuroscience · 2024Review
- In vivo ephaptic coupling allows memory network formation.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Cytoelectric coupling: Electric fields sculpt neural activity and "tune" the brain's infrastructure.Progress in neurobiology · 2023Article
- White matter brain structure predicts language performance and learning success.Human brain mapping · 2023Article
- Fields or firings? Comparing the spike code and the electromagnetic field hypothesis.Frontiers in psychology · 2023Article
- On mathematical modeling of the propagation of a wave ensemble within an individual axon.Frontiers in cellular neuroscience · 2023Review
- Modelling the effect of ephaptic coupling on spike propagation in peripheral nerve fibres.Biological cybernetics · 2022Article
- Dissecting whole-brain conduction delays through MRI microstructural measures.Brain structure & function · 2021Article
- Functional brain plasticity during L1 training on complex sentences: Changes in gamma-band oscillatory activity.Human brain mapping · 2021Article
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Axonal connections are widely regarded as faithful transmitters of neuronal signals with fixed delays. The reasoning behind this is that extracellular potentials caused by spikes travelling along axons are too small to have an effect on other axons. Here we devise a computational framework that allows us to study the effect of extracellular potentials generated by spike volleys in axonal fibre bundles on axonal transmission delays. We demonstrate that, although the extracellular potentials generated by single spikes are of the order of microvolts, the collective extracellular potential generated by spike volleys can reach several millivolts. As a consequence, the resulting depolarisation of the axonal membranes increases the velocity of spikes, and therefore reduces axonal delays between brain areas. Driving a neural mass model with such spike volleys, we further demonstrate that only ephaptic coupling can explain the reduction of stimulus latencies with increased stimulus intensities, as observed in many psychological experiments.
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