ArticleThe international journal of cardiovascular imaging2021
Prognostic significance of cardiac magnetic resonance-based markers in patients with hypertrophic cardiomyopathy.
Article in The international journal of cardiovascular imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Global and Temporal Trends in Utilization and Outcomes of Implantable Cardioverter Defibrillators in Hypertrophic Cardiomyopathy.Circulation. Arrhythmia and electrophysiology · 2025Pooled it
- One- and two-year structural changes of mavacamten therapy in hypertrophic obstructive cardiomyopathy: a case report with serial comprehensive CMR demonstrating continuous reverse remodelling.European heart journal. Case reports · 2026Article
- Novel deep learning framework for simultaneous assessment of left ventricular mass and longitudinal strain: clinical feasibility and validation in patients with hypertrophic cardiomyopathy.Journal of echocardiography · 2025Article
- Global Myocardial Wall Thickness in Transfusion-Dependent Thalassemia: A Cross-Sectional MRI Analysis.Diagnostics (Basel, Switzerland) · 2025Article
- IWT score for predicting cardiac amyloidosis in patients with hypertensive heart disease.The international journal of cardiovascular imaging · 2025Article
- Effects of Mavacamten on Cardiac Magnetic Resonance Features in Chinese Patients With Obstructive Hypertrophic Cardiomyopathy.JACC. Asia · 2025Article
- Cardiac Magnetic Resonance Imaging and Arrhythmic Risk Stratification in Cardiomyopathies.Journal of clinical medicine · 2025Review
- Considerations for drug trials in hypertrophic cardiomyopathy.ESC heart failure · 2025Review
- Subclinical myocardial dysfunction assessed by cardiac magnetic resonance feature tracking predicts ventricular arrhythmias in early-stage hypertension.Frontiers in cardiovascular medicine · 2025Article
- Cardiac troponin T associates with left ventricular function and synchrony assessed by CMR in the general population: results from the Akershus Cardiac Examination 1950 Study.European heart journal. Imaging methods and practice · 2024Article
- Importance of T1-Mapping Sequence in Patients with Hypertrophic Cardiomyopathy without Foci of Non-Ischemic Myocardial Injury in Late Gadolinium Enhancement Sequence.Biomedicines · 2024Article
- Rationale and design of a randomised trial of trientine in patients with hypertrophic cardiomyopathy.Heart (British Cardiac Society) · 2023Article
- Reference ventricular dimensions and function parameters by cardiovascular magnetic resonance in highly trained Caucasian athletes.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2023Article
- Cardiac magnetic resonance-derived tissue tracking strain in patients with hypertrophic cardiomyopathy.Quantitative imaging in medicine and surgery · 2023Article
- The predictive value of cardiac MRI strain parameters in hypertrophic cardiomyopathy patients with preserved left ventricular ejection fraction and a low fibrosis burden: a retrospective cohort study.Frontiers in cardiovascular medicine · 2023Article
- Global research trends of hypertrophic cardiomyopathy from 2000 to 2022: Insights from bibliometric analysis.Frontiers in cardiovascular medicine · 2023Article
- Papillary and Trabecular Muscles Have Substantial Impact on Quantification of Left Ventricle in Patients with Hypertrophic Obstructive Cardiomyopathy.Diagnostics (Basel, Switzerland) · 2022Article
- Comparison of Nonclassic and Classic Phenotype of Hypertrophic Cardiomyopathy Focused on Prognostic Cardiac Magnetic Resonance Parameters: A Single-Center Observational Study.Diagnostics (Basel, Switzerland) · 2022Article
- Multimodality Advanced Cardiovascular and Molecular Imaging for Early Detection and Monitoring of Cancer Therapy-Associated Cardiotoxicity and the Role of Artificial Intelligence and Big Data.Frontiers in cardiovascular medicine · 2022Review
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
The prognosis of patients with hypertrophic cardiomyopathy (HCM) varies greatly. Cardiac magnetic resonance (CMR) is the gold standard method for assessing left ventricular (LV) mass and volumes. Myocardial fibrosis can be noninvasively detected using CMR. Moreover, feature-tracking (FT) strain analysis provides information about LV deformation. We aimed to investigate the prognostic significance of standard CMR parameters, myocardial fibrosis, and LV strain parameters in HCM patients. We investigated 187 HCM patients who underwent CMR with late gadolinium enhancement and were followed up. LV mass (LVM) was evaluated with the exclusion and inclusion of the trabeculae and papillary muscles (TPM). Global LV strain parameters and mechanical dispersion (MD) were calculated. Myocardial fibrosis was quantified. The combined endpoint of our study was all-cause mortality, heart transplantation, malignant ventricular arrhythmias and appropriate implantable cardioverter defibrillator (ICD) therapy. The arrhythmia endpoint was malignant ventricular arrhythmias and appropriate ICD therapy. The LVM index (LVMi) was an independent CMR predictor of the combined endpoint independent of the quantification method (p < 0.01). The univariate predictors of the combined endpoint were LVMi, global longitudinal (GLS) and radial strain and longitudinal MD (MDL). The univariate predictors of arrhythmia events included LVMi and myocardial fibrosis. More pronounced LV hypertrophy was associated with impaired GLS and increased MDL. More extensive myocardial fibrosis correlated with impaired GLS (p < 0.001). LVMi was an independent CMR predictor of major events, and myocardial fibrosis predicted arrhythmia events in HCM patients. FT strain analysis provided additional information for risk stratification in HCM patients.
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