Evidence map›Paper›PMID 33555464›Full record

Trial reportBreast cancer research and treatment2021

The impact of high-intensity interval exercise training on NK-cell function and circulating myokines for breast cancer prevention among women at high risk for breast cancer.

Adriana M Coletta, Nadia H Agha, Forrest L Baker, Grace M Niemiro, Preteesh L Mylabathula, Abenaa M Brewster, Therese B Bevers, Enrique Fuentes-Mattei, Karen Basen-Engquist, Susan C Gilchrist and 1 more

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Breast cancer research and treatment, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02923401 (High-Intensity Interval Training for Women at Heightened Risk for Breast Cancer), which is not on this map. Cited by 36 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 7 pooled it
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02923401 nacompletednot on this map

High-Intensity Interval Training for Women at Heightened Risk for Breast Cancer

TypeinterventionalSponsorM.D. Anderson Cancer CenterRan2016 to 2022Enrolled39ConditionsDisorders of BreastArmsExercise, Questionnaires, Motivational Session, Phone Call, Printed Materials
3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 7 syntheses or guidelines pooled it, 51 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Adriana M ColettaDepartment of Health and Kinesiology, The University of Utah, Salt Lake City, UT, USA. adriana.coletta@hci.utah.edu.ORCID http://orcid.org/0000-0002-2503-2792
Nadia H AghaDepartment of Health and Human Performance, The University of Houston, Houston, TX, USA.
Forrest L BakerDepartment of Pediatrics, The University of Arizona, Tucson, AZ, USA.
Grace M NiemiroDepartment of Pediatrics, The University of Arizona, Tucson, AZ, USA.
Preteesh L MylabathulaDepartment of Pediatrics, The University of Arizona, Tucson, AZ, USA.
Abenaa M BrewsterDepartment of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Therese B BeversDepartment of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Enrique Fuentes-MatteiDepartment of Radiation Oncology Clinical Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Karen Basen-EngquistDepartment of Behavioral Science, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Susan C GilchristDepartment of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Richard J SimpsonDepartment of Pediatrics, The University of Arizona, Tucson, AZ, USA.
The University of Texas MD Anderson Cancer Center · USUniversity of Arizona · USUniversity of Houston · USUniversity of Utah · US

Funding

R25 SUPPLEMENT IN GENETIC EPIDEMIOLOGY EDUCATIONR25CA057730 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI CHANG, SHINE · 1992 to 2016
$18.6M
Integrative Cancer Scholars Training GrantT32CA009213 · NCI · UNIVERSITY OF ARIZONA · PI CAREW, JENNIFER S, CURIEL-LEWANDROWSKI, CLARA · 1985 to 2024
$8.6M
NCI NIH HHS R25 CA057730NCI NIH HHS R25TCA057730, PI: Shine Chang PhDNCI NIH HHS T32 CA009213NCI NIH HHS T32CA009213 (PI: Anne Cress PhD)University of Texas MD Anderson Cancer Center Center for Energy Balance in Cancer Prevention and SurvivorshipUniversity of Texas MD Anderson Cancer Center Energy Balance Assessment Supplemental Funding
6 · The paper itself

Abstract

purposePreclinical evidence suggests that natural killer cell (NK-cell) function and myokines facilitate the protective effects of exercise for breast cancer prevention. Since higher-intensity exercise acutely promotes greater mobilization and larger changes in NK-cell cytotoxicity than lower-intensity, high-intensity interval training (HIIT) might offer increased immune protection compared to moderate-intensity continuous-training (MICT). This study compared a 12-week HIIT program to a 12-week MICT program and usual care on changes in resting NK-cell function and circulating myokines among women at high risk for breast cancer.

methodsThirty-three women were randomized to HIIT, MICT, or usual care, for a supervised exercise intervention. Blood was collected at baseline and end-of-study. The cytotoxic activity of CD3-/CD56+ NK-cells against the K562 target cell line in vitro was determined by flow cytometry. Circulating myokines (IL-15, IL-6, irisin, OSM, osteonectin, IL-7) were assessed with luminex multiplex assays and ELISA. One-way ANOVA and paired sample t-tests assessed between- and within-group differences, respectively. Pearson correlation coefficients determined relationships between baseline fitness and change variables.

resultsSignificant differences were not observed between groups for change in NK-cell function or circulating myokines (p > 0.05). Significant correlations were only observed for baseline peak aerobic capacity (ml/kg/min) and change in NK-cell-specific lysis (r = - 0.43, p = 0.02) and hemacytotoxicity for the total sample (r = - 0.46, p = 0.01).

conclusionOur findings suggest that exercise intensity may not significantly impact change in resting NK-cell function and circulating myokines among women at high risk for breast cancer. Structured exercise training may have a larger impact on NK-cell function in those with lower levels of cardiorespiratory fitness. CLINICAL

trial registrationNCT02923401; Registered on October 4, 2016.

Indexed as

Breast NeoplasmsCardiorespiratory FitnessHigh-Intensity Interval TrainingExerciseExercise TherapyFemaleHumansBreast cancer preventionCytokinesExercise immunology

Identifiers

PMID33555464
PMCPMC8189992
OpenAlexW3127643036

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.