Evidence map›Paper›PMID 33555396›Full record

ArticlePediatric surgery international2021

Remote ischemic conditioning avoids the development of intestinal damage after ischemia reperfusion by reducing intestinal inflammation and increasing intestinal regeneration.

Haitao Zhu, Bo Li, Edoardo Bindi, Carol Lee, Mashriq Alganabi, Maarten Janssen Lok, Agostino Pierro

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Article in Pediatric surgery international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Haitao ZhuDepartment of Pediatric Surgery, Children's Hospital of Fudan University, Shanghai, China.
Bo LiTranslational Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada.
Edoardo BindiTranslational Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada.
Carol LeeTranslational Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada.
Mashriq AlganabiTranslational Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada.
Maarten Janssen LokTranslational Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada.
Agostino PierroDivision of General and Thoracic Surgery, The Hospital for Sick Children, Toronto, ON, Canada. agostino.pierro@sickkids.ca.
Hospital for Sick Children · CAShanghai Children's Medical Center · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aim of the studyMidgut volvulus is a potentially life-threatening condition which is based on intestinal ischemia and reperfusion (I/R) injury. Remote ischemia conditioning (RIC) applied to a limb can protect distant organs such as heart and kidney. The aims of this study were to investigate the effect of RIC on a model of midgut volvulus and to explore its underlying mechanism of action.

methodsSix-weeks old C57BL/6 mice were studied: (a) sham (n = 4): laparotomy alone. (b) Intestinal I/R injury (n = 5): occlusion of the superior mesenteric artery (SMA) for 45 min followed by reperfusion. (c) Intestinal I/R (as in group above) with RIC immediately after reperfusion (n = 5). RIC consisted of 4 cycles of 5 min hind limb ischemia followed by 5 min reperfusion. 24-h after laparotomy, animals were euthanized, and the small intestine (same distance from cecum) was harvested. The intestine was examined for inflammatory cytokines (TNF-α and IL-6), epithelial proliferation marker Ki67 and stem cell marker Lgr5 expression. MAIN

resultsCompared to sham, the small intestine of IR mice had more intestinal damage, increased expression of inflammatory cytokines, decreased intestinal proliferation and stem cell activity. RIC significantly counteracted all these changes.

conclusionsRemote ischemia conditioning avoids intestinal damage due to I/R injury. This beneficial effect is associated with decreased intestinal inflammation and enhanced intestinal regeneration. This study implicates that RIC is a novel non-invasive intervention to reduce the intestinal damage occurring in midgut volvulus.

Indexed as

AnimalsBiomarkersCytokinesExtremitiesInflammationIntestinesIntestine, SmallIschemiaKidneyMaleMiceMice, Inbred C57BLRegenerationReperfusionReperfusion InjuryBiomarkersCytokinesIntestinal damageIschemia and reperfusionMidgut volvulusNeonateRemote ischemic conditioning

Identifiers

PMID33555396
OpenAlexW3188874510

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.