Evidence map›Paper›PMID 33555382›Full record

ArticleExperimental brain research2021

Effects of acquired vestibular pathology on the organization of mouse exploratory behavior.

Mark T Banovetz, Rami I Lake, Ashley A Blackwell, Jenna R Osterlund Oltmanns, Ericka A Schaeffer, Ryan M Yoder, Douglas G Wallace

Abstract read
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Article in Experimental brain research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mark T BanovetzDepartment of Psychology, Northern Illinois University, DeKalb, 60115, USA.
Rami I LakeDepartment of Psychology, Northern Illinois University, DeKalb, 60115, USA.
Ashley A BlackwellDepartment of Psychology, Northern Illinois University, DeKalb, 60115, USA.
Jenna R Osterlund OltmannsDepartment of Psychology, Northern Illinois University, DeKalb, 60115, USA.
Ericka A SchaefferDepartment of Psychology, Northern Illinois University, DeKalb, 60115, USA.
Ryan M YoderDepartment of Psychology, Coastal Carolina University, Conway, 29528, USA.
Douglas G WallaceDepartment of Psychology, Northern Illinois University, DeKalb, 60115, USA. dwallace@niu.edu.ORCID http://orcid.org/0000-0002-4428-1268

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rodent open field behavior is highly organized and occurs spontaneously in novel environments. This organization is disrupted in mice with vestibular pathology, suggesting vestibular signals provide important contributions to this behavior. A caveat to this interpretation is that previous studies have investigated open field behavior in adult mice with congenital vestibular dysfunction, and the observed deficits may have resulted from developmental changes instead of the lack of vestibular signals. To determine which aspects of open field behavior depend specifically on vestibular signals, mouse movement organization was examined under dark and light conditions at two time points, 1 and 2 months, after bilateral chemical labyrinthectomy. Our results show that acquired vestibular damage selectively disrupted the organization of open field behavior. Access to visual environmental cues attenuated, but did not eliminate, these significant group differences. Improvement in movement organization from the first to the second testing session was limited to progression path circuity. These observations provide evidence for the role of the vestibular system in maintaining spatial orientation and establishes a foundation to investigate neuroplasticity in brain systems that process self-movement information.

Indexed as

Exploratory BehaviorVestibule, LabyrinthAnimalsCuesMiceOrientation, SpatialSpace PerceptionDark testingLight testingMovement topographyPath integrationProgressionsStopsVestibular

Identifiers

PMID33555382

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.