ArticleThe Journal of experimental medicine2021
The thymoproteasome hardwires the TCR repertoire of CD8+ T cells in the cortex independent of negative selection.
Article in The Journal of experimental medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Calibrating T cell responsiveness through interactions with self.Nature reviews. Immunology · 2026Review
- Proteasome alteration between epithelial and hematopoietic cells facilitates positive selection of CD8 T cells.Nature communications · 2026Article
- Unraveling CD8 lineage decisions reveals that functionally distinct CD8Nature immunology · 2026Article
- Thymic and T-cell intrinsic critical roles associated with severe combined immunodeficiency and Omenn syndrome due to a heterozygous variant (G201R) in PSMB10.The Journal of allergy and clinical immunology · 2025Article
- The thymoproteasome in shaping the CD8Current opinion in immunology · 2023Review
- CD4Frontiers in immunology · 2023Article
- Proteasome substrate receptors and their therapeutic potential.Trends in biochemical sciences · 2022Review
- PTEN directs developmental and metabolic signaling for innate-like T cell fate and tissue homeostasis.Nature cell biology · 2022Article
- Tissue-specific proteasomes in generation of MHC class I peptides and CD8Current opinion in immunology · 2022Review
- Fine-tuning of β-catenin in mouse thymic epithelial cells is required for postnatal T-cell development.eLife · 2022Article
- Review
- Peptides for T cell selection in the thymus.Peptides · 2021Review
- Know thy immune self and non-self: Proteomics informs on the expanse of self and non-self, and how and where they arise.Proteomics · 2021Review
- Specific impact of β5t on proteasome subunit composition in cortical thymic epithelial cells.Cell reports · 2021Article
- Thymoproteasome optimizes positive selection of CD8Advances in immunology · 2021Review
- The Role of Proteasomes in the Thymus.Frontiers in immunology · 2021Review
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
Abstract
The thymoproteasome expressed specifically in thymic cortical epithelium optimizes the generation of CD8+ T cells; however, how the thymoproteasome contributes to CD8+ T cell development is unclear. Here, we show that the thymoproteasome shapes the TCR repertoire directly in cortical thymocytes before migration to the thymic medulla. We further show that the thymoproteasome optimizes CD8+ T cell production independent of the thymic medulla; independent of additional antigen-presenting cells, including medullary thymic epithelial cells and dendritic cells; and independent of apoptosis-mediated negative selection. These results indicate that the thymoproteasome hardwires the TCR repertoire of CD8+ T cells with cortical positive selection independent of negative selection in the thymus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.