ArticleClinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery2021
Identifying distinct trajectories of acute otitis media in children: A prospective cohort study.
Article in Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Perinatal exposures and upper respiratory tract microbiome composition are associated with age at first acute otitis media episode.bioRxiv : the preprint server for biology · 2026Article
- Early life factors documented in electronic health records predict recurrent acute otitis media.PloS one · 2026Article
- The Long-Term Effect of Childhood Otitis Media on Speech-in-Noise Testing at Ages 9 and 13.Laryngoscope investigative otolaryngology · 2025Article
- Perinatal risk factors and preliminary prediction of conductive hearing loss in infancy.Journal of otology · 2025Article
- [Analysis of the positive rate of otitis media in 1-12 years old children based on brain MRI].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2023Article
- Acute otitis media in children 6 months to 2 years of age.Canadian family physician Medecin de famille canadien · 2022Article
- Identifying distinct trajectories of acute otitis media in children: A prospective cohort study.Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery · 2021Article
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Authors and funding
8 authors.
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Abstract
objectivesTo identify possibly distinct acute otitis media (AOM) trajectories in childhood and identify determinants associated with specific AOM trajectories. To explore which child will become prone to recurrent AOM episodes and which will not.
designPopulation-based prospective cohort study among 7863 children from birth until 10 years and their mothers.
methodsThis study was embedded in the Generation R Study: a population-based prospective cohort study. Data on AOM and determinants were collected by repeated parental questionnaires. Distinct AOM trajectories within the population were identified with latent-class analyses. Next, using multivariate analysis we checked whether specific determinants were associated with specific trajectories.
resultsThree distinct trajectories were identified; that is, non-otitis prone, early AOM-that is children who suffered AOM episodes until 3 years of age but not beyond, and persistent AOM-that is children who remained otitis-prone. Male gender (OR: 1.26, CI: 1.11-1.43) and day-care attendance (OR: 1.31, CI: 1.06-1.60) were associated with increased odds of early AOM. Breastfeeding was beneficial for children in both the early-AOM and persistent-AOM trajectories (OR: 0.78 and 0.77, respectively). Birth in the summer or autumn as compared with birth in the spring decreased odds of AOM only in the persistent-AOM trajectory. Half of all AOM-prone children recovered after the age of 3 years.
conclusionSpecific determinants are associated with different AOM trajectories. Future research is needed to better predict which child will remain otitis-prone and which recovers after the age of 3 years to better tailor treatment towards the needs of the individual child.
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