ArticleJournal of Alzheimer's disease : JAD2021
Mild Behavioral Impairment and Subjective Cognitive Decline Predict Cognitive and Functional Decline.
Article in Journal of Alzheimer's disease : JAD, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers, 2 of them syntheses that pooled it.
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Who cites it
102 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Mild behavioral impairment and risk of incident dementia: A systematic review and meta-analysis.Journal of Alzheimer's disease : JAD · 2026Pooled it
- Risk factors of mild behavioral impairment: a systematic review.Frontiers in psychology · 2025Pooled it
- Effects of traditional Thai folk dance combined with cognitive stimulation program on behavior and cognition among older adults with cognitive decline: A randomized controlled trial.The journal of prevention of Alzheimer's disease · 2025Trial
- Structural Carotid Atherosclerosis and Mild Behavioral Impairment: A Cross-Sectional Study in a Community-Dwelling Population.The Kaohsiung journal of medical sciences · 2026Article
- Phenotyping of mild behavioral impairment domains in multi-regional dementia-free older adults of Chinese ethnicity: impulse dyscontrol as the leading domain.The journal of prevention of Alzheimer's disease · 2026Article
- Combined Influence of Subjective Cognitive Complaints and Neuropsychiatric Symptoms on Cognitive Trajectories in Older Adults.Brain sciences · 2026Article
- Enhancing Alzheimer Disease Detection Using Neuropsychiatric Symptoms: The Role of Mild Behavioural Impairment in the Revised NIA-AA Research Framework.Journal of geriatric psychiatry and neurology · 2026Article
- Lifetime Exposure to Endogenous Estradiol and Markers of Dementia Risk: Associations with Later Life Cognitive, Behavioral, and Functional Complaints.Diagnostics (Basel, Switzerland) · 2026Article
- Non-cognitive symptoms as early indicators of Dementia: a preliminary retrospective study from a Psychiatric outpatient clinic.BMC psychiatry · 2026Article
- Article
- Functional network phenotypes of mild behavioural impairment: cognitive effects moderated by amyloid.Alzheimer's research & therapy · 2026Article
- Mild behavioral impairment is longitudinally associated with frailty in very old adults with MCI: insights from COGFRAIL.Aging clinical and experimental research · 2026Article
- Reframing Dementia Prevention Strategies Aligned with the WHO Global Action Plan: A Structured Narrative Review Focusing on Mild Behavioral Impairment.Neurology international · 2026Review
- Neural mechanisms underlying the effects of visual input on static balance in older adults with mild cognitive impairment.Frontiers in neuroscience · 2026Article
- The Mild Behavioral Impairment Checklist for Parkinson's Disease: An Ancillary Instrument in Cognitive Assessment.Movement disorders clinical practice · 2026Article
- Comparing self and informant perspectives on neuropsychiatric symptoms in older adults in a memory clinic.Journal of Alzheimer's disease : JAD · 2026Article
- Article
- Mild behavioural impairment-apathy and core Alzheimer's disease cerebrospinal fluid biomarkers.Brain : a journal of neurology · 2025Article
- Mild Behavioral Impairment is Associated With Incident Cognitive Decline Among Dementia-Free, Racially Diverse Older Adults: Data From the African Americans Fighting Alzheimer's in Midlife (AA-FAIM) Study.The American journal of geriatric psychiatry. Open science, education, and practice · 2025Article
- Network analysis of neuropsychiatric symptoms in mild behavioral impairment among nursing homes: an observational study.BMC geriatrics · 2025Observational
42 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundMild behavioral impairment (MBI) and subjective cognitive decline (SCD) are dementia risk states, and potentially represent neurobehavioral and neurocognitive manifestations, respectively, of early stage neurodegeneration. Both MBI and SCD predict incident cognitive decline and dementia, are associated with known dementia biomarkers, and are both represented in the NIA-AA research framework for AD in Stage 2 (preclinical disease).
objectiveTo assess the associations of MBI and SCD, alone and in combination, with incident cognitive and functional decline in a population of older adults. We tested the hypothesis that MBI and SCD confer additive risk for decline.
methodsCognitively normal participants were followed up annually at Alzheimer's Disease Centers. Logistic regression assessed the relationship between baseline classification (MBI-SCD-, MBI-SCD+, MBI+SCD-, or MBI+SCD+) and 3-year outcome.
resultsOf 2,769 participants (mean age=76), 1,536 were MBI-SCD-, 254 MBI-SCD+, 743 MBI+SCD-, and 236 MBI+SCD+. At 3 years, 349 (12.6%) declined to CDR >0, including 23.1% of the MBI+group, 23.5% of the SCD+group, and 30.9% of the intersection group of both MBI+and SCD+participants. Compared to SCD-MBI-, we observed an ordinal progression in risk (ORs [95% CI]): 3.61 [2.42-5.38] for MBI-SCD+ (16.5% progression), 4.76 [3.57-6.34] for MBI+SCD- (20.7%), and 8.15 [5.71-11.64] for MBI+SCD+(30.9%).
conclusionMBI and SCD together were associated with the greatest risk of decline. These complementary dementia risk syndromes can be used as simple and scalable methods to identify high-risk patients for workup or for clinical trial enrichment.
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