Evidence map›Paper›PMID 33554862›Full record

ArticleeLife2021

Residue-by-residue analysis of cotranslational membrane protein integration in vivo.

Felix Nicolaus, Ane Metola, Daphne Mermans, Amanda Liljenström, Ajda Krč, Salmo Mohammed Abdullahi, Matthew Zimmer, Thomas F Miller Iii, Gunnar von Heijne

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. SARS-CoV-2 membrane protein biogenesis.bioRxiv : the preprint server for biology · 2026
    Article
  6. Article
  7. Review
  8. Article
  9. Cotranslational membrane insertion of the voltage-sensitive KProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Mechanism of Protein Translocation by the Sec61 Translocon Complex.Cold Spring Harbor perspectives in biology · 2023
    Review
  15. Review
  16. Cotranslational folding and assembly of the dimericProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  17. Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Felix Nicolaus *Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.ORCID 0000-0001-9230-8544
Ane Metola *Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.ORCID 0000-0002-2885-7634
Daphne Mermans *Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.ORCID 0000-0001-6001-5608
Amanda LiljenströmDepartment of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.
Ajda KrčDepartment of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.
Salmo Mohammed AbdullahiDepartment of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.
Matthew ZimmerCalifornia Institute of Technology, Division of Chemistry and Chemical Engineering, Pasadena, United States.ORCID 0000-0002-1437-2636
Thomas F Miller IiiCalifornia Institute of Technology, Division of Chemistry and Chemical Engineering, Pasadena, United States.ORCID 0000-0002-1882-5380
Gunnar von HeijneDepartment of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.ORCID 0000-0002-4490-8569
Stockholm University · SECalifornia Institute of Technology · USUniversity of Ljubljana · SI

Funding

A New Pradigm for the Rational Expression of Integral Membrane ProteinsR01GM125063 · NIGMS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI CLEMONS, WILLIAM M., MILLER, THOMAS FRANCIS · 2017 to 2020
$1.5M
NIGMS NIH HHS R01 GM125063
6 · The paper itself

Abstract

We follow the cotranslational biosynthesis of three multispanning

Indexed as

Protein BiosynthesisAmino Acid MotifsCell MembraneEscherichia coliEscherichia coli ProteinsProtein DomainsEscherichia coli ProteinsbiochemistrybiogenesisBtuCchemical biologycotranslationalE. coliEmrEGlpGmembrane proteinmolecular biophysicsstructural biology

Identifiers

PMID33554862
PMCPMC7886326
OpenAlexW3127852550

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.